Machine Learning to Predict Drug-Induced Liver Injury and its Validation on Failed Drug Candidates in Development
Fahad Mostafa,
Victoria Howle,
Minjun Chen
Abstract:Drug-induced liver injury (DILI) remains a significant challenge for the pharmaceutical industry and regulatory organizations. Despite a plethora of toxicological research aimed at estimating the risk of DILI, the efficacy of these techniques in predicting DILI in humans has remained limited. This has prompted the exploration of new approaches and procedures to improve the prediction accuracy of DILI risk for drug candidates in development. This study aimed to address this gap by leveraging a large human datas… Show more
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