Machine learning for artemisinin resistance in malaria treatment across in vivo-in vitro platforms

Zhang, Hanrui; Guo, Jiantao; Li, Hongyang; Guan, Yuanfang

doi:10.1016/j.isci.2022.103910

Cited by 4 publications

(5 citation statements)

References 56 publications

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“…For example, while we use the processed data from GEO as our example files, we could have also elected to use the raw data the authors provided instead. In that case, we would have preprocessed the datasets individually as described in the methods of our original study ( Zhang et al., 2022 ). Subsequently, Ciclops will perform imputation and cross-platform quantile normalization to normalize the training and test data with respect to each other.…”

Section: Step-by-step Methods Detailsmentioning

confidence: 99%

“…While Ciclops can be applied to datasets from different studies measuring different clinical outcomes, here we illustrate how to use Ciclops using two datasets from GEO, which can be downloaded by using the script in https://github.com/GuanLab/ciclops/tree/main/external_data . Both example datasets were used in our previous analysis ( Zhang et al., 2022 ) and contain binary labels for fast or slow clearance rate of the parasite under study. While it is not necessary to download this data, it may be of interest to test whether Ciclops works as expected in your local environment.…”

Section: Before You Beginmentioning

confidence: 99%

“…This protocol also utilizes SHAP, a post-training analysis allowing for assessing potential biomarkers of the clinical outcome under study. For complete details on the use and execution of this protocol, please refer to Zhang et al. (2022) .…”

mentioning

confidence: 99%

“…For complete details on the use and execution of this protocol, please refer to Zhang et al. (2022) .…”

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confidence: 99%

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Protocol for using Ciclops to build models trained on cross-platform transcriptome data for clinical outcome prediction

Chou¹,

Zhang²,

Guan³

2022

STAR Protocols

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Section: Step-by-step Methods Detailsmentioning

confidence: 99%

Section: Before You Beginmentioning

confidence: 99%

mentioning

confidence: 99%

“…For complete details on the use and execution of this protocol, please refer to Zhang et al. (2022) .…”

mentioning

confidence: 99%

See 2 more Smart Citations

Protocol for using Ciclops to build models trained on cross-platform transcriptome data for clinical outcome prediction

Chou¹,

Zhang²,

Guan³

2022

STAR Protocols

Self Cite

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“…Artemether is supposed to provide quick symptom relief by lowering the quantity of malarial parasites. Lumefantrine has a substantially longer half-life and is thought to kill any remaining parasites [99,100]. For all-over medicines used in the treatment of Malaria, we just give the probability of the drug used to treat Malaria (Percentage may be±)…”

Section: Pharmacodynamicsmentioning

confidence: 99%

A Systematic Review on Malaria Disease and Its Treatments Focus on Artemether Drug

PHALAK,

BODKE,

BODKE

et al. 2024

Int J Curr Pharm Sci

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Malaria is one of the infectious illnesses of the highest scientific significance and importance to international health organizations. Plasmodium falciparum, the parasite responsible for a highly severe form of the disease in Africa, has traditionally received the most attention. However, in the last two decades, the Plasmodium vivax parasite, which is linked to a large number of cases in Latin America, the Middle East, South and Southeast Asia, the Horn of Africa, and Oceania, has sparked enormous interest, owing to published evidence that it can cause severe malaria, among other things. Malaria is a worldwide public health problem, with a saw 247 million cases recorded in 2021. African countries accounted for approximately 94% of all reported cases. So far, over 200 distinct varieties of protozoa have been discovered and identified, with at least 13 of them being pathogenic to humans. The malaria parasite's life cycle is a complex process involving a mosquito with the species Anopheles and a vertebrate host. Artemether is a lipid-soluble artemisinin derivative. It is available in both oral and intramuscular forms. It is also available as a fixed-dose formulation with lumefantrine. Artemether-lumefantrine is one of the ACTs authorized by the WHO and is being used by the majority of countries transitioning from less effective medications to ACTs. However, the emergence of antimalarial medication resistance poses a significant challenge to malaria control. It works by killing the pathogenic organisms responsible for malaria. It is known as an antimalarial medication, and it is more effective than quinine therapies.

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Machine Learning Techniques for Predicting Malaria: Unpacking Emerging Challenges and Opportunities for Tackling Malaria in Sub-saharan Africa

Mbunge,

Milham,

Sibiya

et al. 2023

Lecture Notes in Networks and Systems

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Machine learning for artemisinin resistance in malaria treatment across in vivo-in vitro platforms

Cited by 4 publications

References 56 publications

Protocol for using Ciclops to build models trained on cross-platform transcriptome data for clinical outcome prediction

Protocol for using Ciclops to build models trained on cross-platform transcriptome data for clinical outcome prediction

A Systematic Review on Malaria Disease and Its Treatments Focus on Artemether Drug

Machine Learning Techniques for Predicting Malaria: Unpacking Emerging Challenges and Opportunities for Tackling Malaria in Sub-saharan Africa

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