Machine learning-based tools to model and to remove the off-target effect

Computer vision profiling of neurite outgrowth dynamics reveals spatiotemporal modularity of Rho GTPase signaling

“…4 c ). This approach provides a mean z -score vector that indicates penetrance and polarity for each feature in response to a siRNA perturbation ( Lefort et al, 2015 ). We refer to this z -score vector as the morphodynamic signature (MDS) of the target gene.…”