Artificial Intelligence (AI) can enable the development of next-generation autonomous safety-critical systems in which Machine Learning (ML) algorithms learn optimized and safe solutions. AI can also support and assist human safety engineers in developing safety-critical systems. However, reconciling both cutting-edge and state-of-the-art AI technology with safety engineering processes and safety standards is an open challenge that must be addressed before AI can be fully embraced in safety-critical systems. Many works already address this challenge, resulting in a vast and fragmented literature. Focusing on the industrial and transportation domains, this survey structures and analyzes challenges, techniques, and methods for developing AI-based safety-critical systems, from traditional functional safety systems to autonomous systems. AI
trustworthiness
spans several dimensions, such as engineering, ethics and legal, and this survey focuses on the safety engineering dimension.