Machine learning and biological evaluation-based identification of a potential MMP-9 inhibitor, effective against ovarian cancer cells SKOV3

Sinha, Khushboo; Parwez, Shahid; MV, Shahana; Yadav, Ananya; Siddiqi, Mohammad Imran; Banerjee, Dibyendu

doi:10.1080/07391102.2023.2240416

Cited by 1 publication

(1 citation statement)

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“…They influence angiogenesis by binding to tyrosine kinase receptors (VEGFR)-1, VEGFR-2, and VEGFR-3 with different affinities [ 68 ]. The matrix metalloproteinase (MMP) family can modulate the dynamic remodelling of the ECM, the VEGF pathway and vascular permeability through different signalling axes [ 69 – 71 ]. For example, the MMP-1/protease-activated receptor-1 (PAR1) signalling axis induces vascular permeability to participate in tumour angiogenesis [ 72 ].…”

Section: Introductionmentioning

confidence: 99%

Research progress of exosomes in the angiogenesis of digestive system tumour

Liu,

Wu,

Sang

et al. 2024

Discov Onc

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Malignant tumours of the digestive system cover a wide range of diseases that affect the health of people to a large extent. Angiogenesis is indispensable in the development, and metastasis of tumours, mainly in two ways: occupation or formation. Vessels can provide nutrients, oxygen, and growth factors for tumours to encourage growth and metastasis, so cancer progression depends on simultaneous angiogenesis. Recently, exosomes have been proven to participate in the angiogenesis of tumours. They influence angiogenesis by binding to tyrosine kinase receptors (VEGFR)-1, VEGFR-2, and VEGFR-3 with different affinities, regulating Yap-VEGF pathway, Akt pathway or other signaling pathway. Additionally, exosomes are potential therapeutic vectors that can deliver many types of cargoes to different cells. In this review, we summarize the roles of exosomes in the angiogenesis of digestive system tumours and highlight the clinical application prospects, directly used as targers or delivery vehicles, in antiangiogenic therapy.

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