Machine drill bit for surgical management of shaft of femur fracture in osteopetrosis - A case report of rare disease

Maheshwari, Vikas; Garg, Varun; Sinha, Saurabh; Gowda, Aditya K.S.; Singh, Vivek Ajit

doi:10.1016/j.jorep.2022.100083

Cited by 1 publication

(2 citation statements)

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“…2 3 Varied biochemical parameter with repeated fractures could also been seen in multiple disorders like osteoporosis and osteopetrosis and should be considered. 10…”

Section: Discussionmentioning

confidence: 99%

“…2,3 Varied biochemical parameter with repeated fractures could also been seen in multiple disorders like osteoporosis and osteopetrosis and should be considered. 10 Following clinic-biochemical suspicion of TIO, localization of the causative tumor producing the phosphatonins is a necessity as surgical excision of tumor is associated with good functional outcomes compared to medical management alone. 6 Varied imaging modalities are being used at present like MRI, computed tomography, and nuclear imaging modalities like bone scans, fluorodeoxyglucose-PET scans, and DOTANOC-PET scans.…”

Section: Discussionmentioning

confidence: 99%

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Tumor-Induced Osteomalacia: A Case Report of Rare Disease and Literature review

Bansal

Maheshwari

Niraula

et al. 2023

South Asian J Cancer

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Background Oncogenic osteomalacia term used for tumor-induced osteomalacia (TIO) is a paraneoplastic syndrome of abnormal phosphate metabolism secondary to ectopic endocrine tumors. The diagnosis often becomes difficult due to rarity of occurrence and deficient literature. The reconstruction following resection has its own technical difficulties, which are addressed in this article. Presentation of Case A 39-year-old female presented with pain in bilateral lower limbs and difficulty in mobilizing. The patient had unexplained hypophosphatemia which was diagnosed due to tumor (arising ectopically in greater trochanter), inducing osteomalacia. She was managed successfully with excision of tumor and reconstruction. The biochemical parameters improved drastically within 5 days and fracture healed in 6 weeks' time. Conclusion TIO is a debilitating disease with significant morbidity due to prolonged onset to diagnosis interval and difficulty in localizing the causative tumor. So thorough clinico-radiological and laboratory parameter correlation is a necessity. A rapid diagnosis followed by complete surgical excision, which remains the gold standard treatment modality that confers favorable prognosis in most patients, with strict vigilance for recurrence is required.

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“…2 3 Varied biochemical parameter with repeated fractures could also been seen in multiple disorders like osteoporosis and osteopetrosis and should be considered. 10…”

Section: Discussionmentioning

confidence: 99%