Macathiohydantoins B–K, novel thiohydantoin derivatives from Lepidium meyenii

Yu, Mu-Yuan; Qin, Xu‐Jie; Peng, Xing‐Rong; Wang, Xia; Tian, Xinhui; Li, Zhongrong; Qiu, Ming‐Hua

doi:10.1016/j.tet.2017.05.096

Cited by 23 publications

(31 citation statements)

References 18 publications

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“…Macathiohydantoins B-K are another class of characteristic compounds isolated from maca. They also do not exhibit any cytotoxic or antimicrobial properties against three bacterial strains (S. aureus, E. coli, and P. aeruginosa) and three fungal strains (A. fumigatus, C. parapsilosis, and C. albicans) (Yu et al, 2017a). But structure-wise, these compounds can be of interest.…”

Section: Macahydantoins and Macathiohydantoinsmentioning

confidence: 99%

Is the hype around the reproductive health claims of maca (Lepidium meyenii Walp.) justified?

Beharry¹,

Heinrich²

2018

Journal of Ethnopharmacology

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To date, the health claims of maca cannot be fully supported from a scientific standpoint and more research is needed. It appears that the indigenous local knowledge about the health benefits of maca has been dragged out of context to fit the demands of a growing market for herbal remedies. This globalisation (or hype esp. in China) also has had serious consequences for the local producers in Peru. The lack of protocols to regulate the production and marketing of maca during this rapid expansion, poses a threat to both the safety of consumers and the sustainability of supply.

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Section: Macahydantoins and Macathiohydantoinsmentioning

confidence: 99%

Is the hype around the reproductive health claims of maca (Lepidium meyenii Walp.) justified?

Beharry¹,

Heinrich²

2018

Journal of Ethnopharmacology

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“…The main phytochemicals found in Lepidium meyenii can be categorized into six classes: glucosinolates and isothiocyanates [54,59,63,[68][69][70][71][72], macaene and macamides [47,58,[73][74][75][76][77][78][79][80][81] , alkaloids [52,[82][83][84], thiohydantoins [85][86][87], polysaccharides [43,44,51,55,77,[88][89][90][91][92][93], and fatty acids [46,77,78,94,95]. Here, we discuss the in-depth contribution of polysaccharides to the nutraceutical properties of Lepidium meyenii.…”

Section: Phytochemicalsmentioning

confidence: 99%

Pharmacological Activities of the Nutraceutical Plant Lepidium meyenii: A Critical Review

Carvalho¹,

Ferraz²,

Ribeiro³

2020

J Food Chem Nanotechnol

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Lepidium meyenii is a medicinal edible plant that have nutritional and therapeutic benefits due to synthesis of bioactive compounds. The main phytochemicals found in Lepidium meyenii can be categorized into six classes: glucosinolates and isothiocyanates, thiohydantoins, macaene and macamides, alkaloids, polysaccharides, and fatty acids. These compounds show a wide range of biological activities, which include antioxidant, anti-inflammatory, antimicrobial, cytotoxic, and immunomodulatory activities. Hereby, the objective of this review is to provide a wide comprehension of the nutraceutical properties of Lepidium meyenii. For that, we review and critically discussed original manuscripts describing the chemical and nutritional composition, as well as biological activities of Lepidium meyenii extracts. We showed that the nutraceutical properties of the belowground part of Lepidium meyenii shows great variations that are dependent of differences of phenotype, place of cultivation, type of soil, environmental conditions, and time of harvest. Additionally, we have demonstrated that diet supplementation with Lepidium meyenii may exert several health prophylactics benefits.

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“…3 ). All of them are racemates [ 28 – 31 ]. Zhou et al postulated the biosynthetic pathway of (+)-meyeniins A – C ( 42–44 ), involving the construction of the 2-methylthiazolidine ring by condensation reaction between acetaldehyde and l -cysteine, followed by Edman degradation reaction between 2-methylthiazolidine-4-carboxylic acid and related isothiocyanate (Scheme 2 a) [ 29 ].…”

Section: Chemical Constituents With Bioactivity In Macamentioning

confidence: 99%

“…Only (+)-meyeniin A showed moderately selective cytotoxic activity against the HL-60, A549, and MCF-7 human cell lines. Some compounds were tested for their acetylcholinesterase inhibitory activity, antimicrobial, and antifungal activity, but none of them showed significant activity [ 28 – 31 ].…”

Section: Chemical Constituents With Bioactivity In Macamentioning

confidence: 99%

Progress on the Chemical Constituents Derived from Glucosinolates in Maca (Lepidium meyenii)

Huang

Peng

Qiu

2018

Nat. Prod. Bioprospect.

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Maca (Lepidium meyenii Walp.), a famous food supplement, has drawn an unprecedented international interest over the last two decades. It was assumed that glucosinolates, macamides, macaenes, and alkaloids are the main bioactive components of Maca before. Recently, a series of novel thiohydantoins which generally exhibit a variety of activities have been isolated from Maca. This review focuses on the progress on the main bioactive components of Maca and their biosynthetic pathway, which indicates that macamides, thiohydantoins, and some alkaloids may originate from glucosinolates. Interestingly, thiohydantoins from Maca are the first type of thiohydantoin derivatives to be found from a natural source and may contribute to some significant effects of Maca.Graphical Abstract

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Macathiohydantoins B–K, novel thiohydantoin derivatives from Lepidium meyenii

Cited by 23 publications

References 18 publications

Is the hype around the reproductive health claims of maca (Lepidium meyenii Walp.) justified?

Is the hype around the reproductive health claims of maca (Lepidium meyenii Walp.) justified?

Pharmacological Activities of the Nutraceutical Plant Lepidium meyenii: A Critical Review

Progress on the Chemical Constituents Derived from Glucosinolates in Maca (Lepidium meyenii)

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