Macaque antibodies targeting Marburg virus glycoprotein induced by multivalent immunization
Benjamin M. Janus,
Ruixue Wang,
Thomas E. Cleveland
et al.
Abstract:Marburg virus infection in humans is associated with case fatality rates that can reach up to 90%, but to date, there are no approved vaccines or monoclonal antibody (mAb) countermeasures. Here, we immunized Rhesus macaques with multivalent combinations of filovirus glycoprotein (GP) antigens belonging to Marburg, Sudan, and Ebola viruses to generate monospecific and cross-reactive antibody responses against them. From the animal that developed the highest titers of Marburg virus GP-specific neutralizing antib… Show more
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