Maca (Lepidium meyenii Walp.) on semen quality parameters: A systematic review and meta-analysis

Lee, Hye Won; Lee, Myeong Soo; Fan, Qi-Wen; Lee, Jewon; Kim, Eunseop

doi:10.3389/fphar.2022.934740

Cited by 8 publications

(20 citation statements)

References 32 publications

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“…The use of this phytobooster was found to be significantly and reliably correlated with positive treatment outcomes for male sexual disorders in 7 out of 11 randomized placebo-controlled studies, multiple cohort studies, and pilot studies conducted between 2000 meyenii on several parameters of ejaculate quality in healthy men. Thus, more research is needed to determine the exact impact of Lepidium meyenii on the quality of ejaculates in both infertile and healthy men, as indicated by the data from meta-analyses (Lee et al 2022).…”

Section: Resultsmentioning

confidence: 99%

Modern possibilities of phytotherapy for male infertility from the standpoint of evidence-based medicine

Bratchikov,

Tyuzikov,

Grekov

2023

RRP

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Introduction: Male infertility is an topical medical and social problem of modern reproductive medicine. Its pharmacotherapy is often empirical in nature, and the most popular method remains the use of various herbal substances (phytotherapy), the effectiveness of which remains still understudied in the framework of evidence-based medicine. Materials and Methods: The results of research, thematic, systematic and Cochrane reviews and meta-analyses were searched in Medline/PubMed medical databases over the past 5 years using the search queries "plants male infertility", "plants sperm", "phytotherapy male infertility", "phytomedicinal therapeutics male infertility", "systematic review", "meta-analysis", and "review". Results: The vast majority of herbal substances offered for the treatment of male infertility demonstrate insufficient or contradictory evidence base for their clinical effectiveness, although some of them can be very useful pharmacotherapeutic options in the combined therapy of male infertility. Conclusion: Not all plant substances with a "reproductive effect" positioned in them actually have proven reproductive effects in studies in humans, therefore, the choice of phytotherapeutic agents in the treatment of idiopathic male infertility should be currently approached extremely carefully, especially in cases when we choose phytotherapy as an option for empirical monotherapy of male reproductive disorders.

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Section: Resultsmentioning

confidence: 99%

Modern possibilities of phytotherapy for male infertility from the standpoint of evidence-based medicine

Bratchikov,

Tyuzikov,

Grekov

2023

RRP

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“…It concluded that the evidence was unclear and too scant to support its use. While the authors noted the absence of studies, one of the issues in making a proper assessment was the absence of defining maca colors within the individual studies to examine whether there was a targeted effect of one type of maca over another, which might be anticipated with black maca based on animal data [35]. 9.1.…”

Section: Black Macamentioning

confidence: 99%

Not All Maca Is Created Equal: A Review of Colors, Nutrition, Phytochemicals, and Clinical Uses

Minich,

Ross,

Frame

et al. 2024

Nutrients

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Maca (Lepidium meyenii, Lepidium peruvianum) is part of the Brassicaceae family and grows at high altitudes in the Peruvian Andes mountain range (3500–5000 m). Historically, it has been used as a nutrient-dense food and for its medicinal properties, primarily in enhancing energy and fertility. Scientific research has validated these traditional uses and other clinical applications by elucidating maca’s mechanisms of action, nutrition, and phytochemical content. However, research over the last twenty years has identified up to seventeen different colors (phenotypes) of maca. The color, hypocotyl size, growing location, cultivation, and post-harvest processing methods can have a significant effect on the nutrition content, phytochemical profile, and clinical application. Yet, research differentiating the colors of maca and clinical applications remains limited. In this review, research on the nutrition, phytochemicals, and various colors of maca, including black, red, yellow (predominant colors), purple, gray (lesser-known colors), and any combination of colors, including proprietary formulations, will be discussed based on available preclinical and clinical trials. The gaps, deficiencies, and conflicts in the studies will be detailed, along with quality, safety, and efficacy criteria, highlighting the need for future research to specify all these factors of the maca used in publications.

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“…The protocol was registered at reviewregistry 1346 [19]. The standard methods of performing systematic reviews were followed for this review.…”

Section: Registrationmentioning

confidence: 99%

“…Several in vivo studies have shown that maca can improve sexual behavior and enhance androgen-like effects in rats [14,15]. Systematic reviews have suggested that maca increases sperm count and motility and improves sexual function in humans [13,16,17].…”

Section: Introductionmentioning

confidence: 99%

Maca (L. meyenii) for erectile dysfunction: a systematic review and meta-analysis

2023

Journal of Men's Health

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Maca (Lepidium meyenii) has been reported to improve erectile function (EF). The purpose of this study was to evaluate the clinical evidence for or against maca as a therapy for erectile dysfunction (ED) in men. We searched 11 databases for randomized controlled trials (RCTs) comparing any type of maca with a placebo in the treatment of ED in men. The primary endpoint was EF, while the secondary endpoints were quality of life and adverse events. Risk of bias (ROB) was assessed using the Cochrane ROB tool 2.0. Study selection, data extraction, and assessment were independently performed by two researchers. RevMan 5.4.1 software (Cochrane Collaboration, 2020) was used for data aggregation, and the Grades of Recommendation, Assessment, Development and Evaluation (GRADE) assessment was used to evaluate the quality of the study outcomes. Only two RCTs met all the inclusion criteria. These RCTs examined the effects of maca on EF in patients with mild ED. One RCT showed a positive effect of maca on EF, whereas the other RCT did not. The results of the meta-analysis indicate that maca has positive effects on EF in men with mild ED (n = 79, MDs 1.13: 0.64 to 1.61, p = 0.01; p < 0.0001). Our comprehensive review found limited evidence for the benefits of maca in improving EF. Several limitations, including the total number of studies and their sample sizes, were insufficient to draw firm conclusions. Further studies are needed.

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Maca (Lepidium meyenii Walp.) on semen quality parameters: A systematic review and meta-analysis

Cited by 8 publications

References 32 publications

Modern possibilities of phytotherapy for male infertility from the standpoint of evidence-based medicine

Modern possibilities of phytotherapy for male infertility from the standpoint of evidence-based medicine

Not All Maca Is Created Equal: A Review of Colors, Nutrition, Phytochemicals, and Clinical Uses

Maca (L. meyenii) for erectile dysfunction: a systematic review and meta-analysis

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