MAC reduction after intrathecal coadministration of GABA A agonist and glutamate antagonist in rats

Sumikura, Hiroyuki; Arendt‐Nielsen, Lars

doi:10.1007/s005400300023

Cited by 11 publications

(9 citation statements)

References 27 publications

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“…Thus, we conclude that spinal AMPA receptors may be important targets for the analgesic effects of emulsified enflurane, isoflurane and sevoflurane. This is in accord with the observations of Sumikura and Arendt-Nielsen, 27 who found that i.t. administration YM872 (an AMPA receptor antagonist) produced a maximal decrease of 31.4% in sevoflurane MAC.…”

Section: Discussionsupporting

confidence: 93%

“…Inhalation anaesthetics have been reported to attenuate excitatory neurotransmission in the CNS, particularly at glutamate synapses 3–5 . Intrathecal administration of a glutamate receptor antagonist has also been reported to produce an antinociceptive effect and reduce the MAC 27,28 . The excitatory effect of glutamate on nociception is mediated by at least two distinct classes of receptors, AMPA receptors and N ‐methyl‐ d ‐aspartate(NMDA) receptors.…”

Section: Discussionmentioning

confidence: 99%

“…[3][4][5] Intrathecal administration of a glutamate receptor antagonist has also been reported to produce an antinociceptive effect and reduce the MAC. 27,28 The excitatory effect of glutamate on nociception is mediated by at least two distinct classes of receptors, AMPA receptors and N-methyl-d-aspartate(NMDA) receptors. The AMPA receptors are involved in mediating acute excitation from both A and C fibres, whereas NMDA receptors are involved in the facilitation of pain by repetitive stimulation of C fibres.…”

Section: Discussionmentioning

confidence: 99%

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Spinal Α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic Acid Receptors May Mediate the Analgesic Effects of Emulsified Halogenated Anaesthetics

Hang

Shao

Yang

et al. 2007

Clin Exp Pharma Physio

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1. The present study was designed to investigate the relationship between spinal cord alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors and the analgesic effects of emulsified halogenated anaesthetics. 2. After having established the mouse model of analgesia by intraperitoneal or subcutaneous injections of appropriate doses of emulsified enflurane, isoflurane or sevoflurane, we injected different doses of AMPA intrathecally and observed effects on the pain threshold using the hot-plate and acetic acid-induced writhing tests. 3. The results showed that intrathecal injection of AMPA (0.25, 0.5 and 1.0 ng) did not affect the pain threshold on the hot-plate test or the writhing times in conscious mice. In contrast, AMPA (0.25, 0.5 and 1.0 ng intrathecally) significantly and dose-dependently decreased the pain threshold on the hot-plate test and increased the writhing times in mice treated with emulsified anaesthetics. 4. These results suggest that spinal AMPA receptors may be important targets for the analgesic effects of emulsified enflurane, isoflurane and sevoflurane.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Spinal Α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic Acid Receptors May Mediate the Analgesic Effects of Emulsified Halogenated Anaesthetics

Hang

Shao

Yang

et al. 2007

Clin Exp Pharma Physio

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“…As predicted by our hypotheses, we conclude that spinal AMPA receptors may be important targets for the analgesic effects of emulsified enflurane, isoflurane and sevoflurane. This is in accord with the observation of Sumikura and Arendt‐Nielsen [33] who found that intrathecal administration YM872 (AMPA receptor antagonist) produced a maximal decrease of 31.4% in sevoflurane MAC. Similarly, McFarlane et al .…”

Section: Discussionsupporting

confidence: 92%

α‐Amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic Acid Receptors Participate in the Analgesic but Not Hypnotic Effects of Emulsified Halogenated Anaesthetics

Hang

Shao

Yang

et al. 2008

Basic Clin Pharma Tox

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The present study was designed to investigate the role of α -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in hypnosis and analgesia induced by emulsified inhalation anaesthetics. After having established the mice model of hypnosis and analgesia by intraperitoneally injecting appropriate doses of emulsified enflurane, isoflurane or sevoflurane, we intracerebroventricularly or intrathecally injected different doses of AMPA and then observed the effects on the sleep time using hypnosis test and the tail-withdrawal latency using the tail-withdrawal test. In hypnosis test, AMPA (50, 75 and 100 ng, intracerebroventricularly) had no distinctive effects on the sleep time of the mice treated with emulsified inhalation anaesthetics (P > 0.05). In tail-withdrawal test, AMPA (0.25, 0.5 and 1.0 ng, intrathecally) significantly and dose-dependently decreased the tail-withdrawal latency (P < 0.05 or P < 0.01) in the mice treated with emulsified anaesthetics. These results suggest that AMPA receptors may participate in the analgesic but not in the hypnotic effects induced by emulsified enflurane, isoflurane or sevoflurane.

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“…infusion of MK801 (NMDA receptor antagonist) produced a maximal decrease of 65% in isofl urane MAC. Similarly, Sumikura and Arendt-Nielsen [18] found that i.t. infusion of AP5 produced a maximal decrease of 30% in sevofl urane MAC.…”

Section: Discussionmentioning

confidence: 99%

Spinal N-Methyl-<i>D</i>-Aspartate Receptors May Mediate the Analgesic Effects of Emulsified Halogenated Anesthetics

2006

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The present study was designed to investigate the relationship between spinal cord N-methyl-D-aspartate (NMDA) receptors and the analgesic effects of emulsified halogenated anesthetics. After having established the mouse model of analgesia by intraperitoneally or subcutaneously injecting appropriate doses of emulsified enflurane, isoflurane or sevoflurane, we intrathecally injected different doses of NMDA and then observed the effects on the pain threshold using the hot-plate test and the acetic acid-induced writhing test. The results showed that intrathecal injection of NMDA (2.5, 5 and 10 ng) did not affect the pain threshold on the hot-plate test or the writhing times in conscious mice (p > 0.05); in contrast, NMDA (2.5, 5 and 10 ng intrathecally) can significantly and dose dependently decrease the pain threshold on the hot-plate test (p < 0.05 or p < 0.01) and increase the writhing times (p < 0.05 or p < 0.01) in the mice treated with emulsified anesthetics. These results suggest that spinal NMDA receptors may be important targets for the analgesic effects of emulsified enflurane, isoflurane and sevoflurane.

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MAC reduction after intrathecal coadministration of GABA A agonist and glutamate antagonist in rats

Cited by 11 publications

References 27 publications

Spinal Α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic Acid Receptors May Mediate the Analgesic Effects of Emulsified Halogenated Anaesthetics

Spinal Α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic Acid Receptors May Mediate the Analgesic Effects of Emulsified Halogenated Anaesthetics

α‐Amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic Acid Receptors Participate in the Analgesic but Not Hypnotic Effects of Emulsified Halogenated Anaesthetics

Spinal N-Methyl-<i>D</i>-Aspartate Receptors May Mediate the Analgesic Effects of Emulsified Halogenated Anesthetics

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