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Abstract

We present a clinical case of a rarely diagnosed serous endometrial carcinoma (SEC) with infiltration of the cervix, left parametrium, right fallopian tube, with bilateral ovarian metastases and tumor cells in the peritoneal lavage. After extensive pathohistological and immunohistochemical examinatoin, it was proved to be a locally advanced serous endometrial carcinoma-pT3b N0 M0. The publication discusses the importance of immunohistochemical (IHC) differential diagnosis for determining the histogenesis of papillary serous adenocarcinoma. The main pathohistological dilemma is the determination of the histological subtype of this locally aggressive endometrial carcinoma. Another problem is the definition of the primary origin of the tumor, due to the difference between the pathohistological classification in cervical, uterine and tubo-ovarian adenocarcinomas, as well as the radically different postoperative adjuvant treatment. Incorrect differential diagnosis leads to misdefinition of the necessary complex oncological treatment.