M6A demethylase FTO-mediated downregulation of DACT1 mRNA stability promotes Wnt signaling to facilitate osteosarcoma progression

Lv, Dongming; Ding, S.; Zhong, Li; Tu, Jian; Li, Hongbo; Yao, Hao; Zou, Yutong; Zeng, Ziliang; Liao, Yan; Wan, Xiaoxia; Wen, Li-Li; Xie, Xianbiao

doi:10.1038/s41388-022-02214-z

Cited by 35 publications

(23 citation statements)

References 60 publications

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“…Moreover, METTL3 methylates KRT7-AS to enhance the mRNA stability of keratin 7 (KRT7) depending on IGF2BP1-modified m 6 A, promoting breast cancer lung metastasis 148 . In addition to m 6 A methyltransferases, m 6 A demethylase FTO reduce the stability of DACT1 mRNA by IGF2BP1-modified m 6 A demethylation, facilitating osteosarcoma progression 149 . Recently, IGF2BP1 is reported to promote E2F1-3-driven G1/S transition in an m 6 A-dependent manner in cancer cells 87 .…”

Section: The Role Of Igf2bps As M 6 a Reader In Ca...mentioning

confidence: 99%

The role of Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) as m⁶A readers in cancer

Sun¹,

Cao²,

Du³

et al. 2022

Int. J. Biol. Sci.

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RNA can be modified by over 170 types of distinct chemical modifications, and the most abundant internal modification of mRNA in eukaryotes is N6-methyladenosine (m 6 A). The m 6 A modification accelerates mRNA process, including mRNA splicing, translation, transcript stability, export and decay. m 6 A RNA modification is installed by methyltransferase-like proteins (writers), and potentially removed by demethylases (erasers), and this process is recognized by m 6 A-binding proteins (readers). Notably, alterations of m 6 A-modified proteins (writers, erasers and readers) are involved in the tumorigenesis, progression and metastasis. Importantly, the fate of m 6 A-methylated mRNA is mediated mostly through m 6 A readers, and among these readers, insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) are unique RNA-binding proteins (RBPs) that stabilize their targets mRNA via m 6 A modification. In this review, we update the writers, erasers and readers, and their cross-talks in m 6 A modification, and briefly discuss the oncogenic role of IGF2BPs in cancer. Most importantly, we mainly review the up-to-date knowledges of IGF2BPs (IGF2BP1/2/3) as m 6 A readers in an m 6 A-modified manner in cancer progression.

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Section: The Role Of Igf2bps As M 6 a Reader In Ca...mentioning

confidence: 99%

The role of Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) as m⁶A readers in cancer

Sun¹,

Cao²,

Du³

et al. 2022

Int. J. Biol. Sci.

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“…Secondary HRP-conjugated antibodies were used, and clarity ECL substrate (Bio-Rad) or high-sig ECL substrate (Tanon) was used for detection by MiniChmei Chemiluminescence imager (SAGECREATION, Beijing). 17 …”

Section: Methodsmentioning

confidence: 99%

DNTTIP1 promotes nasopharyngeal carcinoma metastasis via recruiting HDAC1 to DUSP2 promoter and activating ERK signaling pathway

Ding

Gao

et al. 2022

eBioMedicine

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“…The most widely studied RNA methylation regulator is FTO ( Chen and Du, 2019 ). A few potent inhibitors of FTO have been reported in the literature, namely FG-2216/IOX3, FB23-2, rhein, meclofenamic acid (MA), entacapone, bisantren and brequinar ( Mcmurray et al, 2015 ; Van Der Werf and Jamieson, 2019 ; Su et al, 2020 ; Xiao et al, 2020 ; Yang B. et al, 2021 ; Lv et al, 2022 ). FTO was shown to promote tumor glycolysis and limit the response of T cells.…”

Section: Ribonucleic Acid Modifications As Potential Drug Targets In ...mentioning

confidence: 99%

The Key Role of RNA Modification in Breast Cancer

Liu

Zhu

Jiang

et al. 2022

Front. Cell Dev. Biol.

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The modulation of the function and expression of epigenetic regulators of RNA modification has gradually become the hotspot of cancer research. Studies have shown that alteration of epigenetic modifications can promote the development and metastasis of breast cancer. This review highlights the progress in characterization of the link between RNA modification and the prognosis, carcinogenesis and treatment of breast cancer, which may provide a new theoretical basis for development of effective strategies for monitoring of breast cancer based on epigenetics.

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M6A demethylase FTO-mediated downregulation of DACT1 mRNA stability promotes Wnt signaling to facilitate osteosarcoma progression

Cited by 35 publications

References 60 publications

The role of Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) as m⁶A readers in cancer

The role of Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) as m⁶A readers in cancer

DNTTIP1 promotes nasopharyngeal carcinoma metastasis via recruiting HDAC1 to DUSP2 promoter and activating ERK signaling pathway

The Key Role of RNA Modification in Breast Cancer

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M6A demethylase FTO-mediated downregulation of DACT1 mRNA stability promotes Wnt signaling to facilitate osteosarcoma progression

Cited by 35 publications

References 60 publications

The role of Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) as m6A readers in cancer

The role of Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) as m6A readers in cancer

DNTTIP1 promotes nasopharyngeal carcinoma metastasis via recruiting HDAC1 to DUSP2 promoter and activating ERK signaling pathway

The Key Role of RNA Modification in Breast Cancer

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Product

Resources

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The role of Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) as m⁶A readers in cancer

The role of Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) as m⁶A readers in cancer