2019
DOI: 10.21037/atm.2019.02.47
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M2 macrophages promote pulmonary endothelial cells regeneration in sepsis-induced acute lung injury

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Cited by 37 publications
(37 citation statements)
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“…Most notably, macrophages of the M2 phenotype have a greater phagocytotic function resulting in increased clearance of apoptotic cells and an acceleration of resolution ( 39 ). Indeed, M2 macrophages protect against sepsis-induced lung injury ( 51 ) and sepsis-induced acute kidney injury ( 52 ). Transplantation of M2 macrophages has been suggested as a potential therapeutic approach for sepsis-induced lung injury ( 51 ).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Most notably, macrophages of the M2 phenotype have a greater phagocytotic function resulting in increased clearance of apoptotic cells and an acceleration of resolution ( 39 ). Indeed, M2 macrophages protect against sepsis-induced lung injury ( 51 ) and sepsis-induced acute kidney injury ( 52 ). Transplantation of M2 macrophages has been suggested as a potential therapeutic approach for sepsis-induced lung injury ( 51 ).…”
Section: Discussionmentioning
confidence: 99%
“…Indeed, M2 macrophages protect against sepsis-induced lung injury ( 51 ) and sepsis-induced acute kidney injury ( 52 ). Transplantation of M2 macrophages has been suggested as a potential therapeutic approach for sepsis-induced lung injury ( 51 ).…”
Section: Discussionmentioning
confidence: 99%
“…Imbalanced inflammation, uncontrolled accumulation of leukocytes and platelets, and the change in tissues barriers are the main pathophysiological characteristics of acute lung injury [ 19 ]. MaR1 is known to participate in various pharmacological functions, such as cells immunoreaction [ 20 ], tissue regeneration, and pain [ 21 ]. However, whether MaR1 has a protective effect in THS-induced lung injury and the underlying mechanisms in disease progress are still not well understood.…”
Section: Discussionmentioning
confidence: 99%
“…CDH11 have a positive relationship not only with the infiltration level of macrophages in the TME of GC but also with cytokines secreted by macrophages and gene markers such as CCL2, CXCL12, and TGFB1 of TAMs and IL10, IL1R1, CD163, and MRC1 of M2. As inducers, CCL2, TGFB1, CXCL12, and MMP2 not only recruit more macrophages into the TME but also facilitate their polarization and the generation of more M2 macrophages [ 12 , 54 58 ]. High expression of M2-related markers often reflects the increased proportion of M2 macrophages in the TME [ 20 , 37 , 59 ].…”
Section: Discussionmentioning
confidence: 99%