M2 macrophage‑derived exosomes alleviate KCa3.1 channel expression in rapidly paced HL‑1 myocytes via the NF‑κB (p65)/STAT3 signaling pathway
Huiyu Chen,
Huafen Liu,
Dishiwen Liu
et al.
Abstract:The present study was designed to explore the role of M2 macrophage-derived exosomes (M2-exos) on the KCa3.1 channel in a cellular atrial fibrillation (AF) model using rapidly paced HL-1 myocytes. M2 macrophages and M2-exos were isolated and identified. MicroRNA (miR)-146a-5p levels in M2 macrophages and M2-exos were quantified using reverse transcription-quantitative PCR (RT-qPCR). HL-1 myocytes were randomly divided into six groups: Control group, pacing group, pacing + coculture group (pacing HL-1 cells coc… Show more
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