m1A RNA Modification in Gene Expression Regulation

Jin, Hao; Huo, Chunxiao; Zhou, Tianhua; Xie, Shanshan

doi:10.3390/genes13050910

Cited by 35 publications

(23 citation statements)

References 62 publications

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“…Moreover, different methylation types show diversity in preferred target RNAs and modification sites ( 109–111 ). Since the methylations account for >50% of 170 different types of naturally occurring modifications in RNAs ( 110 ), it is necessary to develop a system-wide method/tool to facilitate their efficient detection, as well as to explore the molecular mechanism of RNA methylation in target RNAs and their corresponding roles in disease development and drug response.…”

Section: Discussionmentioning

confidence: 99%

M6AREG: m6A-centered regulation of disease development and drug response

Liu

Chen

Zhang

et al. 2022

Nucleic Acids Research

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As the most prevalent internal modification in eukaryotic RNAs, N6-methyladenosine (m6A) has been discovered to play an essential role in cellular proliferation, metabolic homeostasis, embryonic development, etc. With the rapid accumulation of research interest in m6A, its crucial roles in the regulations of disease development and drug response are gaining more and more attention. Thus, a database offering such valuable data on m6A-centered regulation is greatly needed; however, no such database is as yet available. Herein, a new database named ‘M6AREG’ is developed to (i) systematically cover, for the first time, data on the effects of m6A-centered regulation on both disease development and drug response, (ii) explicitly describe the molecular mechanism underlying each type of regulation and (iii) fully reference the collected data by cross-linking to existing databases. Since the accumulated data are valuable for researchers in diverse disciplines (such as pathology and pathophysiology, clinical laboratory diagnostics, medicinal biochemistry and drug design), M6AREG is expected to have many implications for the future conduct of m6A-based regulation studies. It is currently accessible by all users at: https://idrblab.org/m6areg/

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Section: Discussionmentioning

confidence: 99%

M6AREG: m6A-centered regulation of disease development and drug response

Liu

Chen

Zhang

et al. 2022

Nucleic Acids Research

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“…m 1 A is prevalent in mitochondrial-encoded transcripts, and through the study of manipulating m 1 A level by a mitochondrial located m 1 A methyltransferase trmt61b, it was found that m 1 A interferes with the translation of mitochondrial mRNA [ 43 ]. Methylation of tRNA is accomplished by a family of RNA methyltransferases (mases), which has more than 60 members in humans [ 89 ]. TRMT61A and TRMT6 are responsible for m 1 A58 modification of cytoplasmic tRNAs [ 44 ].…”

Section: Rna Modificationsmentioning

confidence: 99%

The Role of RNA Modification in HIV-1 Infection

Wang

Lian

et al. 2022

IJMS

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RNA plays an important role in biology, and more than 170 RNA modifications have been identified so far. Post-transcriptional modification of RNA in cells plays a crucial role in the regulation of its stability, transport, processing, and gene expression. So far, the research on RNA modification and the exact role of its enzymes is becoming more and more comprehensive. Human immunodeficiency virus 1 (HIV-1) is an RNA virus and the causative agent of acquired immunodeficiency syndrome (AIDS), which is one of the most devastating viral pandemics in history. More and more studies have shown that HIV has RNA modifications and regulation of its gene expression during infection and replication. This review focuses on several RNA modifications and their regulatory roles as well as the roles that different RNA modifications play during HIV-1 infection, in order to find new approaches for the development of anti-HIV-1 therapeutics.

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“…Alternatively, m 1 A can form hydrogen bonds with other nucleosides through Hoogsteen base pairing, which is relatively unstable compared to the normal A:U or A:T base pairing. In the case of chemical transformation, m 1 A can undergo Dimroth rearrangement under alkaline conditions to form m 6 A 5 , 40 , 64 ( Figure 1A ). However, recent studies mainly focused on m 6 A, unlike m 1 A, which was relatively poorly studied.…”

Section: The Function Of Rna Modifications From Transcription To Tran...mentioning

confidence: 99%

RNA Modifications Meet Tumors

Yang¹,

Zhang²,

Xia³

et al. 2022

CMAR

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RNA modifications occur through the whole process of gene expression regulation, including transcription, translation, and post-translational processes. They are closely associated with gene expression, RNA stability, and cell cycle. RNA modifications in tumor cells play a vital role in tumor development and metastasis, changes in the tumor microenvironment, drug resistance in tumors, construction of tumor cell-cell “internet”, etc. Several types of RNA modifications have been identified to date and have various effects on the biological characteristics of different tumors. In this review, we discussed the function of RNA modifications, including N 6 -methyladenine (m 6 A), 5-methylcytosine (m 5 C), N 7 -methyladenosine (m 7 G), N 1 -methyladenosine (m 1 A), pseudouridine (Ψ), and adenosine-to-inosine (A-to-I), in the microenvironment and therapy of solid and liquid tumors.

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m1A RNA Modification in Gene Expression Regulation

Cited by 35 publications

References 62 publications

M6AREG: m6A-centered regulation of disease development and drug response

M6AREG: m6A-centered regulation of disease development and drug response

The Role of RNA Modification in HIV-1 Infection

RNA Modifications Meet Tumors

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