M1712 High Hepatotoxic Overdose of Paracetamol Produces Generalized Convulsions and Brain Damage in Rats. a Counteraction with the Stable Gastric Pentadecapeptide BPC 157 (PL 14736)

Pentadecapeptide BPC 157 and its effects on a NSAID toxicity model: Diclofenac-induced gastrointestinal, liver, and encephalopathy lesions

“…All tests were measured using an Olympus AU2700 analyzer with original test reagents (Olympus Diagnostica, Lismeehan, Ireland) (Ilic et al 2010(Ilic et al , 2009Sikiric et al 1993b;Prkacin et al 2001b).…”

“…Microvesicular steatosis was scored from 1-3: 1 -less than 20% of hepatocytes showing microvesicular steatosis, 2 -20-60% of hepatocytes showing microvesicular steatosis and 3 -over 60% of hepatocytes showing microvesicular steatosis. Parenchymal necrosis, eosinophilic cytoplasm, pyknotic nuclei and conspicuous nucleoli were scored semiquantitatively as follows: 0 -showing no changes, 1 -minimum, 2 -moderate and 3 -maximum changes (Ilic et al 2010(Ilic et al , 2009Sikiric et al 1993b;Prkacin et al 2001b). …”

“…Initially, BPC 157 counteracted aspirin-, indomethacin-and diclofenac-induced gastrointestinal lesions and adjuvant arthritis (Sikiric et al 1996(Sikiric et al , 1997a. Very recently, it was shown to reduce liver and brain lesions caused by NSAIDs (Ilic et al 2010). In addition, the authors analyzed its effects on paracetamol, which rapidly induces hepatic encephalopathy with generalized convulsions unless BPC 157 is given intraperitoneally or intragastrically in the early or advanced stages of paracetamol toxicity (Ilic et al 2010).…”

“…It is likely that BPC in both the upper and lower gastrointestinal tract (Sikiric et al 2010(Sikiric et al , 1996(Sikiric et al 1997a(Sikiric et al ,b, 2001Klicek et al 2008;Skorjanec et al 2009;Sever et al 2009) that is stable in human gastric juice and was proven to be effective in inflammatory bowel disease trials (PL 14736) (for review see Sikiric et al 2010) and for various wound treatments (Skorjanec et al, 2009;Sever et al 2009, Sikiric et al 2003Tkalcevic et al 2007) with no toxicity reported (for review see Sikiric et al 2010). It may also affect many disturbances of the central nervous system (Blagaic et al 2004;Boban Blagaic et al 2005;Tohyama et al 2004;Jelovac et al 1998Jelovac et al , 1999Sikiric et al 1999;Tudor et al 2010) and contain various hepatoprotective effects (Ilic et al 2010(Ilic et al , 2009Sikiric et al 1993a;Prkacin et al 2001b). In support of these studies, there is evidence that BPC 157 antagonizes stomach-liver-brain lesions induced by an overdose of insulin (Ilic et al 2009).…”

Nephroprotective and antioxidant properties of Artemisia arborescens hydroalcoholic extract against oestroprogestative-induced kidney damages in rats

“…Liver and kidney play a very important role in the metabolism of estrogens and progestogens, and it has become clear that these substances may act directly or indirectly on the renal and hepatic tissue to produce a variety of biological effects of both physiological and pathological significance [4,5].…”