M1487: Preliminary Experience With Biodegradable Stents in the Treatment of Refractary Benign Gastrointestinal Strictures

Viedma, Bartolomé López; Lorente, Rufo; Domper, Francisco; Santa, E. de la; Cabanillas, Manuel; Paton, R. Y.; Verdejo, Cristina; Hernández, A. Rodríguez; Olmedo, José Javier Serrano; Rodriguez, Eduardo D.

doi:10.1016/j.gie.2010.03.487

Cited by 3 publications

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“…The degradation process is accelerated by a low pH and acid-suppressing therapy (proton-pump inhibitors) is recommended to prolong stent integrity. A limited number of cohort studies have been reported with the ELLA-BDS for management of benign esophageal diseases such as benign esophageal strictures (BES), refractory benign esophageal stricture (RBES) [ 3 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 ] ( Figure 6 ) and achalasia [ 61 ] ( Table 1 ). Technical success, clinical responses and outcomes were different.…”

Section: Clinical Studies With Biodegradable Esophageal Stentsmentioning

confidence: 99%

“…In contrast to the PLLA-BDS, the ELLA-BDS has shown some promising results. An initial case series with the ELLA-BDS for esophageal strictures [ 51 , 56 , 58 , 62 , 63 ] showed a low migration rate (0% to 22%) and an acceptable clinical success rate (33% to 60%). Current research has shown the uncovered ELLA-BDS allows stent embedding to the esophageal wall and significantly reduces the migration rate but can induce significant hyperplastic tissue reactions [ 52 , 53 , 55 , 61 , 63 ].…”

Section: Clinical Studies With Biodegradable Esophageal Stentsmentioning

confidence: 99%

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Polymeric Biodegradable Stent Insertion in the Esophagus

et al. 2016

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Esophageal stent insertion has been used as a well-accepted and effective alternative to manage and improve the quality of life for patients diagnosed with esophageal diseases and disorders. Current stents are either permanent or temporary and are fabricated from either metal or plastic. The partially covered self-expanding metal stent (SEMS) has a firm anchoring effect and prevent stent migration, however, the hyperplastic tissue reaction cause stent restenosis and make it difficult to remove. A fully covered SEMS and self-expanding plastic stent (SEPS) reduced reactive hyperplasia but has a high migration rate. The main advantage that polymeric biodegradable stents (BDSs) have over metal or plastic stents is that removal is not require and reduce the need for repeated stent insertion. But the slightly lower radial force of BDS may be its main shortcoming and a post-implant problem. Thus, strengthening support of BDS is a content of the research in the future. BDSs are often temporarily effective in esophageal stricture to relieve dysphagia. In the future, it can be expect that biodegradable drug-eluting stents (DES) will be available to treat benign esophageal stricture, perforations or leaks with additional use as palliative modalities for treating malignant esophageal stricture, as the bridge to surgery or to maintain luminal patency during neoadjuvant chemoradiation.

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Section: Clinical Studies With Biodegradable Esophageal Stentsmentioning

confidence: 99%

Section: Clinical Studies With Biodegradable Esophageal Stentsmentioning

confidence: 99%

Polymeric Biodegradable Stent Insertion in the Esophagus

et al. 2016

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Biodegradable Polymeric Esophagus Stents

Hobson

Dhinakar

Shi

et al. 2017

ACS Symposium Series

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Biodegradable stent placement in the esophagus

Boeckel¹,

Vleggaar²,

Siersema³

2013

Expert Review of Medical Devices

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Biodegradable stents overcome some of the problems encountered with self-expanding metal stents. They main advantage over self-expanding metal stents is that endoscopic removal is not needed. Single biodegradable stents are often only temporarily effective in patients with a refractory benign esophageal stricture, as in the majority dysphagia recurs. If this occurs, sequential biodegradable stent placement may be an effective alternative to avoid the burden of serial dilations. In the future, it can be expected that (covered) biodegradable stents will be available to treat benign esophageal perforations/leaks, but also that they will be used for treating malignant indications combined with other (palliative) modalities, such as bridge to surgery or to maintain luminal patency during neoadjuvant chemoradiation.

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M1487: Preliminary Experience With Biodegradable Stents in the Treatment of Refractary Benign Gastrointestinal Strictures

Cited by 3 publications

References 0 publications

Polymeric Biodegradable Stent Insertion in the Esophagus

Polymeric Biodegradable Stent Insertion in the Esophagus

Biodegradable Polymeric Esophagus Stents

Biodegradable stent placement in the esophagus

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