M1113 Clarithromycin or Levofloxacin in First-Line Triple and Sequential Regimens for Helicobacter pylori Eradication: A Randomized Clinical Trial

Assessment of Helicobacter pylori eradication rate of triple combination therapy containing levofloxacin

“…combination is more effective in the fist-line treatment than the triple treatment containing clarithromycin (92.9% vs 83.9%); levofloxacin may also be effective in clarithromycin-and metronidazole-resistant H. pylori strains (10). Levofloxacin-based and sequential therapy is superior to the standard triple scheme as a first-line regimen in a setting with high clarithromycin resistance (31).…”

Antibiotic treatment forHelicobacter pylori: Is the end coming?

“…According to a metaanalysis, 10-d of levofloxacin triple therapy is more efficacious than 7-d bismuth-based quadruple therapy (RR = 1.41, 95%CI: 1.25-1.59) in the eradication of H. pylori infection [113] . In another study, levofloxacinbased triple therapy (ITT, 80.8%; 95%CI: 73%-88%) was more effective than STT (ITT: 64%, 95%CI: 55%-73%) and there were no differences in compliance or side effects [114] . However, other studies reported that levofloxacin-containing regimens did not have superior eradication rates compared to other treatments.…”

Letter: levofloxacin resistance - a challenge for treatment ofHelicobacter pyloriinfection. Authors' reply

“…1,2 Our responses are as follows. First, the trial conducted by Molina-Infante et al 3 in 2010 was included in our meta-analysis, and was cited as reference 7 in the supplementary materials.…”

“…First, the trial conducted by Molina-Infante et al 3 in 2010 was included in our meta-analysis, and was cited as reference 7 in the supplementary materials. 2 The characteristics of the trial were listed in supplementary tables 1 and 2 (both in the 'first line' category). 2 Second, we agreed with Zamani et al's viewpoint that doubling the dosage of proton pump inhibitor (PPI) may achieve higher eradication rates in triple therapy containing clarithromycin.…”

“…2 The characteristics of the trial were listed in supplementary tables 1 and 2 (both in the 'first line' category). 2 Second, we agreed with Zamani et al's viewpoint that doubling the dosage of proton pump inhibitor (PPI) may achieve higher eradication rates in triple therapy containing clarithromycin. 4 However, none of the previous randomised trials compared the efficacy of high dose and standard dose of PPI in triple therapy containing levofloxacin.…”