M1071 Sequential Therapy or Triple Therapy for Helicobacter pylori Infection: Systematic Review and Meta-Analysis of Randomized Controlled Trials in Adult and Children

Gatta, Luigi; Vaira, Dino; Leandro, Gioacchino; Mario, F. Di; Vakil, Nimish B.

doi:10.1016/s0016-5085(09)61574-2

Cited by 107 publications

(176 citation statements)

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“…These criteria have been recommended by an expert panel for use in clinical trials of H. pylori. All patients found to be infected were offered 10-day sequential therapy [12].…”

Section: Helicobacter Pylori Statusmentioning

confidence: 99%

A comparison amongst three rapid urease tests to diagnose Helicobacter pylori infection in 375 consecutive dyspeptic

et al. 2010

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Rapid diagnostic tools for Helicobacter pylori are important in endoscopy. To assess the accuracy of a new 5-min rapid urease test (UFT300, ABS Cernusco, sul Naviglio, Italy) compared with the 1-h Pyloritek (Serim Laboratories, Elkhart, IN) and the 24-h CLO test (Kimberly-Clark Ballard Medical Products, Roswell, GA), consecutive dyspeptic patients referred to our unit for endoscopy were prospectively studied. All patients underwent a 13C-urea-breath test, histology and the UFT300 (ABS; Cernusco, sul Naviglio, Italy). Two additional rapid urease tests were performed. Patients were deemed infected when both 13C-UBT and histology were positive. Rapid urease tests were read at 1, 5, and 60 min, respectively. Of the 375 enrolled patients, 45.3% were infected with H. pylori. The sensitivity of the new 5-min rapid urease test 300 was 90.3, 94.5, and 96.2% at 1, 5, and 60 min, respectively (specificity 100%). The Pyloritek and the new 5-min rapid urease test were comparable, but the CLO test was not reliable at 5 and 60 min. In conclusion, the new 5-min rapid urease test is comparable to the Pyloritek test, but the CLO test is significantly less sensitive at early time points. Reading the test results at 1 min may increase false-negative results with decreasing sensitivity.

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“…These criteria have been recommended by an expert panel for use in clinical trials of H. pylori. All patients found to be infected were offered 10-day sequential therapy [12].…”

Section: Helicobacter Pylori Statusmentioning

confidence: 99%

A comparison amongst three rapid urease tests to diagnose Helicobacter pylori infection in 375 consecutive dyspeptic

et al. 2010

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“…Their data suggest that sequential therapy achieves 12 percent better absolute eradication rate than standard PPI triple therapy 17 .…”

Section: Doimentioning

confidence: 99%

Comparative study of sequential therapy versus standard triple therapy versus quinolone-based triple therapy for eradication of Helicobacter pylori infection

2017

Int. J. Curr. Res. Med. Sci.

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Introduction: H. pylori is a gram-negative bacillus that has naturally colonized humans. Essentially all H. pyloricolonized persons have gastric tissue responses, but fewer than 15% develop associated illnesses such as peptic ulceration, gastric adenocarcinoma, or gastric lymphoma. Worldwide, more than 80% of duodenal ulcers and more than 60% of gastric ulcers are related to H. pylori colonization. Although H. pylori is susceptible to a wide range of antibiotics in vitro, monotherapy is not usually successful. Failure of monotherapy has prompted the development of multidrug regimens, the most successful of which are triple and quadruple combinations. Aims and Objectives: To compare efficacy of Sequential Therapy versus Standard Triple Therapy versus Quinolone-based Triple Therapy for eradication of Helicobacter Pylori infection. Methods: The study included 150 patients attending OPD / admitted in various wards of a tertiary care hospital diagnosed to be helicobacter pylori positive by rapid urease test, after obtaining informed consent. The patients were then be randomly divided into three groups each of 50, one had received Sequential Therapy, other triple therapy and third quinolone based therapy. Results and conclusion: Sequential therapy group had better eradication rates (90%) as compared to standard triple therapy group (86%) and fluroquinolone therapy group (82%) but results were not statistically significant when all three groups were compared together.

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“…21,22 Several meta-analyses and pooled data analyses, mostly from Italy, confirmed between 2007 and 2009 the advantage of 10-day sequential over 7-or 10-day triple therapy, with mean cure rates greater than 90%. [23][24][25][26] In 2012 and 2013, 2 updated meta-analyses 27,28 and 2 systematic reviews, 29,30 including studies from Asia, Europe, and Latin America, exhibited mean eradication rates notably lower (79%-84%) than those reported in early Italian trials. These poor results were confirmed in a global meta-analyses in 2013 with overall cure rates of 84% (95% confidence interval 82.1%-86.4%), besides confirming the lack of advantage over 14-day triple therapy.…”

Section: Sequential Therapymentioning

confidence: 99%

Practical Aspects in Choosing a Helicobacter pylori Therapy

Molina–Infante

Shiotani

2015

Gastroenterology Clinics of North America

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M1071 Sequential Therapy or Triple Therapy for Helicobacter pylori Infection: Systematic Review and Meta-Analysis of Randomized Controlled Trials in Adult and Children

Cited by 107 publications

References 0 publications

A comparison amongst three rapid urease tests to diagnose Helicobacter pylori infection in 375 consecutive dyspeptic

A comparison amongst three rapid urease tests to diagnose Helicobacter pylori infection in 375 consecutive dyspeptic

Comparative study of sequential therapy versus standard triple therapy versus quinolone-based triple therapy for eradication of Helicobacter pylori infection

Practical Aspects in Choosing a Helicobacter pylori Therapy

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