M1 macrophage exosomes engineered to foster M1 polarization and target the IL-4 receptor inhibit tumor growth by reprogramming tumor-associated macrophages into M1-like macrophages

Gunassekaran, Gowri Rangaswamy; Vadevoo, Sri Murugan Poongkavithai; Baek, Moon‐Chang; Lee, Byungheon

doi:10.1016/j.biomaterials.2021.121137

Cited by 234 publications

(154 citation statements)

References 59 publications

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“…The reversible polarization of macrophages is a double-edged sword for cancer therapy. On one hand, a wide variety of pharmaceutical interventions could be utilized to drive M1 polarization and achieve tumoricides ( 149 – 151 ). On the other hand, high plasticity correlates with a high chance of being adversely influenced by environmental factors once pharmacological interventions are withdrawn ( 152 ).…”

Section: Translational Potential Of Macrophage-associated Epigenetic Modifications and Perspectivementioning

confidence: 99%

Epigenetic Modifications in Tumor-Associated Macrophages: A New Perspective for an Old Foe

2022

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Tumorigenesis is frequently accompanied by chronic inflammation, and the tumor microenvironment (TME) can be considered an ecosystem that consists of tumor cells, endotheliocytes, fibroblasts, immune cells and acellular components such as extracellular matrix. For tumor cells, their survival advantages are dependent on both genetic and epigenetic alterations, while other cells mainly present epigenetic modifications. Macrophages are the most plastic type of immune cells and undergo diverse epigenetic alterations in the TME. Some of these epigenetic modifications mitigate against cancer progression, and others accelerate this process. Due to the complex roles of macrophages in the TME, it is urgent to understand their epigenetic modifications associated with the TME. Here, we mainly summarize recent findings on TME-associated epigenetic alterations of tumor-associated macrophages (TAMs), including DNA methylation, posttranslational modifications of histone proteins, chromatin remodeling, and noncoding RNA-mediated epigenetic regulation. At the end of this review, we also discuss the translational potential of these epigenetic modifications for developing novel cancer therapies targeting TAMs.

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Section: Translational Potential Of Macrophage-associated Epigenetic Modifications and Perspectivementioning

confidence: 99%

Epigenetic Modifications in Tumor-Associated Macrophages: A New Perspective for an Old Foe

2022

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“…The potential of the TAM targeted approach for OS treatment is increasingly accepted. Exosomes from M1 macrophages engineered to target IL-4 receptors of TAM have been shown to transform TAMs into M1 phenotypes and suppress OS growth in vivo by increasing immune response to the tumor [94].…”

Section: Msc-evs In Immune Responsementioning

confidence: 99%

Mesenchymal Stem Cells and Extracellular Vesicles in Osteosarcoma Pathogenesis and Therapy

Sarhadi

Daddali

Seppänen‐Kaijansinkko

2021

IJMS

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Osteosarcoma (OS) is an aggressive bone tumor that mainly affects children and adolescents. OS has a strong tendency to relapse and metastasize, resulting in poor prognosis and survival. The high heterogeneity and genetic complexity of OS make it challenging to identify new therapeutic targets. Mesenchymal stem cells (MSCs) are multipotent stem cells that can differentiate into adipocytes, osteoblasts, or chondroblasts. OS is thought to originate at some stage in the differentiation process of MSC to pre-osteoblast or from osteoblast precursors. MSCs contribute to OS progression by interacting with tumor cells via paracrine signaling and affect tumor cell proliferation, invasion, angiogenesis, immune response, and metastasis. Extracellular vesicles (EVs), secreted by OS cells and MSCs in the tumor microenvironment, are crucial mediators of intercellular communication, driving OS progression by transferring miRNAs/RNA and proteins to other cells. MSC-derived EVs have both pro-tumor and anti-tumor effects on OS progression. MSC-EVs can be also engineered to deliver anti-tumor cargo to the tumor site, which offers potential applications in MSC-EV-based OS treatment. In this review, we highlight the role of MSCs in OS, with a focus on EV-mediated communication between OS cells and MSCs and their role in OS pathogenesis and therapy.

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“…Another gel developed by Pengyu Guo et al contained gold nanorods and iron oxide nanoparticles for thermal therapy and M1 polarization, respectively [ 119 ]. Exosomes from M1 were like natural liposomes that carry pro-inflammatory cytokines to promote macrophage M1 polarization with or without modification [ 120 , 121 ]. Graphene oxide (GO) was also able to polarize macrophages in a size-dependent way when large GO induced M1 polarization and promoted inflammatory reactions both in vivo and in vitro.…”

Section: Other Nanomaterialsmentioning

confidence: 99%

Emerging Nanoparticle Strategies for Modulating Tumor-Associated Macrophage Polarization

Shi

2021

Biomolecules

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Immunotherapy has made great progress in recent years, yet the efficacy of solid tumors remains far less than expected. One of the main hurdles is to overcome the immune-suppressive tumor microenvironment (TME). Among all cells in TME, tumor-associated macrophages (TAMs) play pivotal roles because of their abundance, multifaceted interactions to adaptive and host immune systems, as well as their context-dependent plasticity. Underlying the highly plastic characteristic, lots of research interests are focused on repolarizing TAMs from M2-like pro-tumor phenotype towards M1-like antitumoral ones. Nanotechnology offers great opportunities for targeting and modulating TAM polarization to mount the therapeutic efficacy in cancer immunotherapy. Here, this mini-review highlights those emerging nano-approaches for TAM repolarization in the last three years.

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M1 macrophage exosomes engineered to foster M1 polarization and target the IL-4 receptor inhibit tumor growth by reprogramming tumor-associated macrophages into M1-like macrophages

Cited by 234 publications

References 59 publications

Epigenetic Modifications in Tumor-Associated Macrophages: A New Perspective for an Old Foe

Epigenetic Modifications in Tumor-Associated Macrophages: A New Perspective for an Old Foe

Mesenchymal Stem Cells and Extracellular Vesicles in Osteosarcoma Pathogenesis and Therapy

Emerging Nanoparticle Strategies for Modulating Tumor-Associated Macrophage Polarization

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