M012 Serum Sickness-Like Reaction After Pegaspargase Administration With Subsequent Tolerance of Non-Pegylated Asparaginase

Delayed serum sickness reaction after initial hypersensitivity reaction to calaspargase during treatment for B‐cell acute lymphoblastic leukemia

“…This case presented similarly to ours, as the patient developed a rash, pruritus, and refusal to walk 11 days post a hypersensitivity reaction to pegaspargase. 10 We did not find any reports of serum sickness reactions related to calaspargase administration. With the increased use of calaspargase, we suspect there might be further cases like the one we describe.…”