M₂and M₃-muscarinic acetylcholine receptors remodelling in patients with a dilated atrium

Abstract

Remodelling of M2 and M3 receptors is not associated with AF, but with the dilated left atrium.

Effect of synthesis temperature and alkoxy side chain length on molecular structure and photoelectrochemical properties of terthiophenes

“…It also allows improving the degree of polymerization by the careful selection of the synthesis temperature and the film thickness. [29][30][31] The surface of electrosynthesized PDM and PDP films is visually homogeneous, independently of the substrate used (either Pt or ITO). The cyclic voltammograms (second cycle) acquired during the synthesis of PDM and PDP on ITO substrate at different synthesis temperatures are shown in Figure 2.…”

Interaction of Tetrandrine with Human Serum Albumin: a Fluorescence Quenching Study

“…Here F0 represents the fluorescence intensities in the absence of quencher, F represents the corrected fluorescence intensities in the presence of quencher (the correction method is same as that early employed by us), 9 Kq is the quenching rate constant of the bimolecule, KSV is the dynamic quenching constant, τ0 is the average lifetime of the molecule without quencher (the τ0 for the biopolymer is often taken as 10 -8 s) 13,14 and [Q] is the concentration of the quencher. In order to confirm the quenching mechanism, the procedure of the fluorescence quenching was first assumed to be dynamic quenching.…”

“…[3][4][5][6][7] But so far only a few reports on the reactions between the effective component in Chinese herbal medicines and serum albumin have been reported. [8][9][10] Fluorescence spectroscopy (FS) and ultraviolet spectroscopy (UV) have been widely used to study the interactions between the small molecules and bio-macromolecules. [3][4][5][6][7][8][9][10] From the measurements and analyses of the fluorescence emission spectra, the fluorescence lifetime, fluorescence polarization, etc., a vast amount of information can be procured about the structural fluctuations and the microenvironment changes surrounding the fluorophore in the macromolecule.…”

“…[8][9][10] Fluorescence spectroscopy (FS) and ultraviolet spectroscopy (UV) have been widely used to study the interactions between the small molecules and bio-macromolecules. [3][4][5][6][7][8][9][10] From the measurements and analyses of the fluorescence emission spectra, the fluorescence lifetime, fluorescence polarization, etc., a vast amount of information can be procured about the structural fluctuations and the microenvironment changes surrounding the fluorophore in the macromolecule. [3][4][5][6][7][8][9][10][11][12] In this study, the interaction of TET with HSA has been investigated by using FS and UV.…”

“…[3][4][5][6][7][8][9][10] From the measurements and analyses of the fluorescence emission spectra, the fluorescence lifetime, fluorescence polarization, etc., a vast amount of information can be procured about the structural fluctuations and the microenvironment changes surrounding the fluorophore in the macromolecule. [3][4][5][6][7][8][9][10][11][12] In this study, the interaction of TET with HSA has been investigated by using FS and UV. The experimental results showed that TET could quench the inner fluorescence of HSA and that both static quenching and non-radiation energy transfer were the main reasons resulting in the fluorescence quenching.…”