M‐mode and cross‐sectional echocardiographic diagnosis of right ventricular cavity masses

Krivokapich, Janine; Warren, Sanford E.; Child, John S.; Kaufman, Joseph A.; Vieweg, W. Victor R.; Hagan, Arthur D.

doi:10.1002/jcu.1870090103

Cited by 13 publications

(5 citation statements)

References 18 publications

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“…As for the immediate cause of death, cases in which tumor emboli of the lungs led to death have been reported, similar to our case [6, 10, 11]. If the emboli had been found and treated earlier, the symptoms could have been alleviated and the patient's prognosis could have been improved.…”

Section: Discussionsupporting

confidence: 83%

A Case of Cardiac Metastasis from Uterine Cervical Carcinoma

Okamoto

Kusumoto

Seki

et al. 2015

Case Reports in Obstetrics and Gynecology

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Cases of cardiac metastasis from uterine cervical carcinoma are rare. While they are occasionally found on autopsy, antemortem recognition is extremely rare. We confirmed a case of cardiac metastasis from cervical carcinoma antemortem, because we observed a decrease in platelet count during the course of treatment. The patient was a 27-year-old woman diagnosed with stage Ib1 uterine cervical carcinoma. Radical hysterectomy with pelvic lymphadenectomy was performed. Para-aortic lymph node metastasis was detected on positron emission tomography/computed tomography (PET-CT). Adjuvant chemotherapy was started, and most of the metastatic lesions disappeared. Pelvic lymph node recurrence was suspected on PET-CT during continued chemotherapy; therefore, treatment was shifted to radiation therapy. Tumor shrinkage was recognized, and the initial therapy was completed. A noticeable decrease in platelet count was recognized seven months after treatment. Multidetector CT was performed, and an intracardiac tumor was detected. The patient did not desire any further treatment. She died three weeks after the intracardiac tumor was confirmed. Few previous autopsy studies have reported cardiac metastasis from cervical carcinoma. Thus, it is necessary to consider the possibility of cardiac metastasis for patients diagnosed with terminal cervical carcinoma.

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Section: Discussionsupporting

confidence: 83%

A Case of Cardiac Metastasis from Uterine Cervical Carcinoma

Okamoto

Kusumoto

Seki

et al. 2015

Case Reports in Obstetrics and Gynecology

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“…Electrocardiogram frequently exhibited low voltages and T-wave abnormalities in chest leads, which is indicative of myocardial disability and/or pericardial effusion ( 10 , 13 , 14 , 17 , 19 , 21 – 23 ). Echocardiography revealed a right ventricular mass in the majority of cases ( 1 , 6 , 10 – 12 , 14 , 16 – 18 , 20 – 24 ). In the present case, it was not obvious to suspect cardiac metastasis from the complaints of epigastric discomfort and general malaise exhibited by the patient.…”

Section: Discussionmentioning

confidence: 99%

Solitary cardiac metastasis of uterine cervical cancer with antemortem diagnosis: A case report and literature review

et al. 2016

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Cardiac metastasis of uterine cervical cancer with antemortem diagnosis is extremely rare. Therefore, its landscape epidemiology has not been well elucidated to date. In the present study, a case of solitary cardiac metastasis of uterine cervical cancer diagnosed antemortem is reported, and a review of the currently available literature (which includes 18 cases of cardiac metastasis of uterine cervical cancer) is conducted. In January 2013, a 78-year-old woman with squamous cell carcinoma (SCC) of the uterine cervix (International Federation of Gynecology and Obstetrics stage IIIb) underwent definitive radiotherapy at Gunma University Hospital (Gunma, Japan). Follow-up examination at 5 months after completion of the treatment indicated no evidence of recurrence or metastasis. In April 2014, the patient reported epigastric discomfort and general malaise. Electrocardiogram suggested myocardial dysfunction. Transthoracic echocardiography revealed the presence of a mass occupying the right ventricle and pericardial effusion. Cine magnetic resonance imaging demonstrated a filling defect in the right ventricle, and transcatheter biopsy confirmed SCC. The patient was diagnosed with a solitary cardiac metastasis of uterine cervical cancer. Despite aggressive medical therapy, the patient succumbed to disease 31 days after admission to hospital. A review of the current literature revealed that 84% of cases of cardiac metastasis develop within 2 years of completion of the initial treatment, and that electrocardiogram and echocardiography reveal findings of myocardial dysfunction and the presence of a mass in the right ventricle, respectively. A treatment strategy for cardiac metastasis of uterine cervical cancer has not been standardized thus far, and the prognosis is very poor, as the majority of patients succumbed to disease within 1 year. In summary, the current case and the literature review conducted in the present study suggest that: i) Cardiac metastasis should be included in the differential diagnosis in cases with nonspecific complaints such as epigastric discomfort and general malaise when patients have a history of uterine cervical cancer, particularly within the previous 2 years; and ii) electrocardiogram and echocardiography are convenient and effective modalities for the diagnosis of cardiac metastasis of uterine cervical cancer.

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“…A review of the English language literature revealed that only 13 well‐documented cases of right ventricular (intracavitary) metastases from cervical cancer have been described 6 –16 . The 14 cases (including the present case) are summarized in Table 2.…”

Section: Discussionmentioning

confidence: 99%

“…Metastatic tumor may be totally intracavitary; usually following implants of tumor cells on the endocardium 22 . According to the literature, intracavitary mass without ventricular invasion accounts for 40% (4/10) of cases 8 –10 , 14 . The mean age of these patients is 46 years (range, 28–77 years).…”

Section: Discussionmentioning

confidence: 99%

“…Uterine cervical carcinoma with cardiac metastases is less common; 2 , 3 , 5 with endocardial (intracavitary) metastases being particularly rare. Only 13 cases with right intracavitary metastasis are found in the English literature 6 –16 . We present an autopsy case of squamous cell carcinoma (SCC) of the uterine cervix that developed intraventricular metastasis, and a review of other reported cases.…”

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confidence: 99%

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Right intraventricular metastasis of squamous cell carcinoma of the uterine cervix: An autopsy case and literature review

Senzaki

Uemura

Yamamoto

et al. 1999

Pathology International

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An autopsy case of squamous cell carcinoma of the uterine cervix, which developed cardiac intracavitary metastasis in a 28-year-old Filipina, is reported. At autopsy, the right ventricle contained a soft, red-purple, cauliflower-like mass. Histologically, this mass was made up of sheets of malignant squamous cells similar to the primary uterine foci. The metastases were extensive and associated with multiple organ involvement. Although this case was stage Ib at operation, vascular invasion at the primary site was characteristic, and the intracavitary tumor of the right ventricle developed without myocardial involvement. The carcinoma of the primary site extended along the inferior vena cava and settled as an intracardiac obstructive mass. A literature review (including the present case) disclosed only 14 uterine cervical carcinomas with right intracavitary metastasis. The mean age of these patients was 46 years of age (range, 28-77 years). The clinical stage was Ib in two cases, IIa in one case, IIb in six cases, and IIIb in two cases. The prognosis of these cases was poor; 13 of the patients died at an average of 19.1 months after diagnosis.

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M‐mode and cross‐sectional echocardiographic diagnosis of right ventricular cavity masses

Cited by 13 publications

References 18 publications

A Case of Cardiac Metastasis from Uterine Cervical Carcinoma

A Case of Cardiac Metastasis from Uterine Cervical Carcinoma

Solitary cardiac metastasis of uterine cervical cancer with antemortem diagnosis: A case report and literature review

Right intraventricular metastasis of squamous cell carcinoma of the uterine cervix: An autopsy case and literature review

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