M�ller glial cells in anuran retina

Bringmann, Andreas; Skatchkov, Serguei N.; Pannicke, Thomas; Biedermann, Bernd; Wolburg, Hartwig; Orkand, Richard K.; Reichenbach, Andreas

doi:10.1002/1097-0029(20000901)50:5<384::aid-jemt7>3.0.co;2-w

Cited by 22 publications

(14 citation statements)

References 86 publications

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“…Similarly, specific protocols are necessary to activate Ca 2+ ‐dependent K + channels. Bringmann et al () recorded currents through iberiotoxin‐sensitive Ca 2+ ‐dependent K + channels in Müller cells from Bufo marinus , which is in agreement with data from Ambystoma tigrinum (Newman, ). Moreover, Newman () described an A‐type current, which is likely to be mediated by Kv channels.…”

Section: Amphibianssupporting

confidence: 77%

“…The function of the glutamate transporter in amphibian Müller cells has been described in a number of studies by David Attwell and coworkers [see Table (Part B)]. Currents evoked by 100 µM glutamate were recorded in Müller cells from Bufo marinus (Bringmann et al, ). Amplitudes of glutamate‐evoked inward currents of Müller cells from Bufo marinus are shown in Fig.…”

Section: Amphibiansmentioning

confidence: 99%

“…Although some electrophysiological investigations exist from Müller cells of other vertebrate classes, they are widely scattered in the literature. Reviews summarizing comparative electrophysiological data from Müller cells were focussed on mammals (Chao et al, ) and anurans (Bringmann et al, ). This review will give an overview for all vertebrates.…”

Section: Introductionmentioning

confidence: 99%

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Comparative electrophysiology of retinal Müller glial cells—A survey on vertebrate species

Pannicke

Chao²,

Reisenhofer

et al. 2016

Glia

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Müller cells are the dominant macroglial cells in the retina of all vertebrates. They fulfill a variety of functions important for retinal physiology, among them spatial buffering of K ions and uptake of glutamate and other neurotransmitters. To this end, Müller cells express inwardly rectifying K channels and electrogenic glutamate transporters. Moreover, a lot of voltage- and ligand-gated ion channels, aquaporin water channels, and electrogenic transporters are expressed in Müller cells, some of them in a species-specific manner. For example, voltage-dependent Na channels are found exclusively in some but not all mammalian species. Whereas a lot of data exist from amphibians and mammals, the results from other vertebrates are sparse. It is the aim of this review to present a survey on Müller cell electrophysiology covering all classes of vertebrates. The focus is on functional studies, mainly performed using the whole-cell patch-clamp technique. However, data about the expression of membrane channels and transporters from immunohistochemistry are also included. Possible functional roles of membrane channels and transporters are discussed. Obviously, electrophysiological properties involved in the main functions of Müller cells developed early in vertebrate evolution. GLIA 2017;65:533-568.

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Section: Amphibianssupporting

confidence: 77%

Section: Amphibiansmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Comparative electrophysiology of retinal Müller glial cells—A survey on vertebrate species

Pannicke

Chao²,

Reisenhofer

et al. 2016

Glia

Self Cite

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“…Müller cells are known to support neuronal activity and maintain the proper functioning of the iBRB under normal conditions [59]. They are involved in the control and homeostasis of K + and other ions signaling molecules, and in the control of extracellular pH [60]. Dysfunction of Müller cells may contribute to a breakdown of the iBRB in many pathological conditions, such as diabetes [61].…”

Section: Blood-retinal Barriermentioning

confidence: 99%

Recent Advances in Ocular Drug Delivery Systems

2011

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Abstract:Transport of drugs applied by traditional dosage forms is restricted to the eye, and therapeutic drug concentrations in the target tissues are not maintained for a long duration since the eyes are protected by a unique anatomy and physiology. For the treatment of the anterior segment of the eye, various droppable products to prolong the retention time on the ocular surface have been introduced in the market. On the other hand, direct intravitreal implants, using biodegradable or non-biodegradable polymer technology, have been widely investigated for the treatment of chronic vitreoretinal diseases. There is urgent need to develop ocular drug delivery systems which provide controlled release for the treatment of chronic diseases, and increase patient's and doctor's convenience to reduce the dosing frequency and invasive treatment. In this article, progress of ocular drug delivery systems under clinical trials and in late experimental stage is reviewed.

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“…1 Also essential for neuronal energy metabolism, Müller cells release pyruvate/lactate to fuel the Krebs cycle of neighboring neurons. 2,3 In addition to their known functions, Müller glia have hypothesized roles in retinal degeneration, 4,5 retinal neurogenesis, 6 and the visual cycle of cone photoreceptors. 7, 8 Müller cells are reported to have a stereotyped activation response to photoreceptor stress caused by disease or injury, 9 resulting in upregulation of secreted neurotrophic factors such as basic fibroblast growth factor (bFGF) and ciliary neurotrophic factor (CNTF).…”

mentioning

confidence: 99%