Untitled

Abstract

The Ras-ERK cell signaling regulates transcription of DNA methyl-transferases (DNMTs). A role of H 2 S in regulation of the Ras-ERK signaling activity and DNMTs expression has also been shown. Here we propose a hypothesis that H 2 S regulates the Ras-ERK signaling-dependent DNMTs transcription. Oxidative stress, lipid metabolism, protein sulfhydration, nitrosylation and nitration are the main targets of regulation by H 2 S. These cell processes are important for the post-translational modifications (PTMs) of the Ras-ERK signaling pathway enzymes. We provide evidence for the dependence of DNMTs transcription on the PTMs of the enzymes of the Ras-ERK signaling pathway regulated by H 2 S. K e y w o r d s:Ras-ERK cell signaling, DNA methyltransferases, H 2 S