Lytic Paget Disease as a Cause of Orbital Cholesterol Granuloma

Pathogenesis of orbital cholesterol granuloma

“…proposed that the initial haemorrhage was a consequence of an unrecognized anomaly within the diploë 11 . More recently, Pagetoid bone has been reported at the periphery of an orbital cholesterol granuloma, raising the possibility that the granuloma arose within an area of Paget's disease 12 . An alternate theory suggested the possibility of abnormally pneumatized frontal bone, with a pathogenesis similar to that seen within the temporal bone 11 .…”

Solitary Orbital Paget Disease: A Case Report

“…Orbital presentation of Paget disease is varied from an indolent, painless, solitary lesion of the orbit to pro-gressive proptosis with sarcomatous transformation (Miller et al, 1999;Goldberg et al, 2000). Similarly, our patient presented with an isolated lesion of orbit with normal serum alkaline phosphatase level.…”

“…The bony orbital disorder that affects posterior 2. aspects of the greater or lesser wings of the sphenoid bone and anterior clinoid process, causing narrowing of the superior orbital fissure and optic canal, with subsequent proptosis, limitation of eye movement, and optic neuropathy (Eretto et al, 1984;Buckler et al, 1987;Kheterpal et al, 1994;Miller at al., 1999). Skull base Paget disease may cause compressive sixth nerve palsy (Pane, 2007).…”

Orbitofrontal cholesterol granuloma

“…10 It has also been described in association with lytic Paget disease. 11 It is still unclear whether a cholesterol granuloma is caused by a diploic anomaly with secondary haemorrhage or a vascular anomaly with secondary osteolysis.…”