Lytic lesion of the sternum. Rare manifestation of sarcoidosis

Oven, Thomas J.; Sones, Maurice; Morrissey, William L.

doi:10.1016/0002-9343(86)90022-7

Cited by 12 publications

(2 citation statements)

References 10 publications

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“…102,110 Anecdotal responses to CSs have been cited, but data are limited to a few case reports. 12,115,116,137,138 CSs increase the risk of osteoporosis and the potential for pathological fractures, and they exacerbate bone loss; additional complications of CSs include avascular necrosis and vertebral compression fractions. 83,110,139,140 Given the potential for serious CS adverse effects, NSAIDs are an alternative to CSs for ameliorating symptoms.…”

Section: Treatmentmentioning

confidence: 99%

Sarcoidosis Involving the Musculoskeletal System

Zisman¹,

Shorr²,

Lynch³

2002

Seminars in Respiratory and Critical Care Medicine

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Although sarcoidosis can affect virtually any organ, musculoskeletal involvement is infrequent. Early in the course of the disease, acute polyarthritis may be observed in up to 40% of patients, but this is often self-limited. Chronic or recurrent sarcoid arthritis is rare, affecting only 1 to 4% of patients. Asymptomatic involvement of muscles has been reported in 25 to 75% of patients in small series, but symptomatic involvement of muscles is rare. Although prospective studies assessing the prevalence of muscle involvement in sarcoidosis have not been done, several large retrospective studies suggest that symptomatic muscle involvement occurs in < 0.5% of patients with sarcoidosis. Patterns of sarcoid muscle involvement include chronic, progressive myopathy; nodular or tumorous sarcoidosis affecting muscles; and an acute polymyositis-like syndrome. Corticosteroid therapy is usually efficacious for the acute myositis variant but is less consistently helpful in the other forms (e.g., chronic myopathy or nodules). Similarly, clinically significant involvement of bone is rare (< 2-5%), and is often associated with chronic multisystemic disease, lupus pernio, and chronic uveitis. Unfortunately, osseous sarcoidosis is often unresponsive to therapy. In this review, we discuss the prevalence, clinical features, and management of sarcoidosis involving muscle, joints, and bones.

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Section: Treatmentmentioning

confidence: 99%

Sarcoidosis Involving the Musculoskeletal System

Zisman¹,

Shorr²,

Lynch³

2002

Seminars in Respiratory and Critical Care Medicine

View full text Add to dashboard Cite

show abstract

“…Lytic lesions without sclerosis have been described in sarcoidosis in the skull and nasal bones as well as once in a rib [5] and twice in the sternum [6,7]. Examples of diffuse bony destruction have been reported at sites other than the spine and pelvis, particularly in long bones [9,11].…”

Section: Discussionmentioning

confidence: 99%