The increasing antibiotic resistance conferred by Staphylococcus aureus to multiple potential antibiotics has become a serious issue of concern and threat to mankind worldwide. In light of this, phage lytic proteins have been reported which show potential antimicrobial activity against pathogenic microorganisms that could be a promising alternative to antibiotics to eradicate the antibiotic resistant problems. This review discusses the various applications of S. aureus phage lytic proteins and the potentiality of aureophage phi 11 endolysin and virion associated peptidoglycan hydrolase (VAPGH) against staphylococcus strains. Phage Phi11 endolysin harbors two enzymatically active domain; cysteine and histidine-dependent amidohydrolase/peptidase (CHAP) and Amidase 2 at the N-terminus and a cell wall binding domain (CBD) SH3 5 at the C-terminus, while virion associated peptidoglycan hydrolase (VAPGH) has two catalytic domains, CHAP and Glucosaminidase (Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase) at its N-terminal and C-terminal, respectively.