Lysosome-targeting turn-on red/NIR BODIPY probes for imaging hypoxic cells

Abstract

Two lysosome-targeting turn-on red/NIR BODIPY probes for imaging hypoxic cells were rationally designed.

Carbazole-based green and blue-BODIPY dyads and triads as donors for bulk heterojunction organic solar cells

“…Among the various types of small molecule photovoltaic materials, 4,4-difluoro-4-bora-3a,4adiaza-s-indacene (BODIPY) dyes have attracted tremendous interest and have been considered to be excellent photoelectric materials owing to their outstanding photophysical properties, such as high molar extinction coefficients, high fluorescence quantum yields, excellent chemical stability, various redox activity, relatively long excited state lifetimes, high thermal and photo-stabilities, [31][32][33] which have led to their application in many fields including bioimaging, 34,35 nonlinear optics, 36,37 photodynamic therapy, 38 organic light-emitting diode, 39,40 dye-sensitized solar cells (DSSC) 2,41,42 and OSCs. 1 In addition, BODIPY derivatives are easily synthesized, and their photophysical and electrochemical characteristics can be easily fine-tuned though an appropriate synthetic modification on the BODIPY core.…”

A Fluorogenic Far Red-Emitting Molecular Viscometer for Ascertaining Lysosomal Stress in Live Cells and Caenorhabditis elegans

“…Later, the indole moiety is suitably functionalized with a well-explored lysosome targeting group morpholine ( JIND-Mor ) Scheme 1 . Morpholine-appended fluorescent probes are known to localize selectively inside lysosomal compartment due to its protophilic nature associated with the low p K a value in the range of 5–6 ( Wang et al, 2013 ; Li et al, 2018 ; Kong et al, 2019 ; Biswas et al, 2021 ).…”

Reductase and Light Programmatical Gated DNA Nanodevice for Spatiotemporally Controlled Imaging of Biomolecules in Subcellular Organelles under Hypoxic Conditions

“…Subcellular organelles (mitochondria, nucleus, lysosomes, etc.) as important organelles are involved in many significant physiological processes, such as cell proliferation, intracellular transport, and biological metabolism. , Dysfunction of these organelles would cause various abnormal regulations and many serious diseases. , Not surprisingly, mitochondrial dysfunction is associated with a variety of human diseases, including neurodegenerative and neuromuscular disorders, ischemia–reperfusion injury, and cancer. , Based on this, lots of research works have been focused on the study of subcellular organelles. − Hypoxia, as a typical feature of a solid tumor, , has been widely recognized to induce cellular dysfunction and lead to incredible changes of biomolecules in subcellular organelles, such as hydrogen ions in lysosomes, adenosine triphosphate (ATP) in mitochondria, and so forth. − Monitoring the changes of biomolecules in subcellular organelles under hypoxic conditions would provide deeper insights into hypoxia-related metabolic pathways, further helping us to recognize various diseases on the subcellular level. However, there is still a lack of probe system capable of monitoring the state of organelles under hypoxic conditions.…”