Lysosome- and plasma membrane-accumulative and tumor-targetable polythiophene nanoparticles for enhanced sonodynamic therapy

Pang, E; Xing, Xuejian; Zhao, Shaojing; Tan, Qiuxia; Pan, Tangna; Yu, Ting; Gan, Yabing; Wang, Benhua; Tan, Siyi; Zhang, Yi; Yin, Peng; Song, Xiangzhi; Lan, Minhuan

doi:10.1039/d3tb00236e

Cited by 2 publications

(1 citation statement)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We speculated that this may be because of the prolonged alkyl chain that sterically hindered the cyanine against oxidative degradation, especially under light. As seen from the optimal molecular structure analysis (Figure d), the cyanine scaffold of IR780-TPP-C 12 is well embedded in the long and flexible dodecyl side chains, which may be responsible for the resistance against the oxidative cleavage and show higher photostability …”

Section: Resultsmentioning

confidence: 99%

Synergetic Pyroptosis with Apoptosis Improving Phototherapy of Mitochondria-Targeted Cyanines with Superior Photostability

Zhao,

Ma,

et al. 2024

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Pyroptosis has been reported to improve the antitumor effect by evoking a more intense immune response and a therapeutic effect. For phototherapy, several photosensitizers have been found to initiate pyroptosis. However, the effect of pyroptosis associated with apoptosis in enhancing the antitumor therapy needs sufficient characterization, especially under longterm treatment. As a NIR photosensitizer, heptamethine cyanines have been discovered for anticancer phototherapy for deep tissue penetration and inherent tumor-targeted capability. However, they are not quite stable for long-term performance. To investigate the effect of pyroptosis along with apoptosis on the anticancer immune responses and phototherapy, here, we chemically modulate the cyanine IR780 to regulate hydrophobicity, stability, and intracellular targeting. Two photosensitizers, T780T-TPP and T780T-TPP-C 12 , were finally optimized and showed excellent photostability with high photothermal conversion efficiency. Although the cellular uptake of the two molecules was both mediated by OATP transporters, T780T-TPP induced tumor cell death via pyroptosis and apoptosis and accumulated in tumor accumulation, while T780T-TPP-C 12 was prone to accumulate in the liver. Ultimately, via one injection-multiple irradiation treatment protocol, T780T-TPP displayed a significant antitumor effect, even against the growth of large tumors (200 mm 3 ).

show abstract

Section: Resultsmentioning

confidence: 99%