Lysosomale Enzyme in Lymphozyten

Brittinger, G.; König, E; Cohnen, G; Hg, Aberle

doi:10.1159/000208682

Cited by 22 publications

(1 citation statement)

References 18 publications

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“…This view is consistent with the kinetic and immunologic evidence of heterogeneity. It is also supported by the finding of a decreased level of the lysosomal enzymes P-glucuronidase and acid phosphatase in the cells of some patients with CLL (11). Further studies are required to determine the possible effect of cell age, bone marrow vs. thymic origin, or the clinical course of the disease on this enzyme.…”

Section: Discussionmentioning

confidence: 92%

Heterogeneity of 5′-Nucleotidase Activity in Lymphocytes in Chronic Lymphocytic Leukemia

Lopes¹,

Zucker‐Franklin²,

Silber³

1973

J. Clin. Invest.

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Section: Discussionmentioning

confidence: 92%

Heterogeneity of 5′-Nucleotidase Activity in Lymphocytes in Chronic Lymphocytic Leukemia

Lopes¹,

Zucker‐Franklin²,

Silber³

1973

J. Clin. Invest.

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In vitro lymphocyte response to phytohemagglutinin and pokeweed mitogen in Hodgkin's disease

Cohnen

Douglas

König

et al. 1973

Cancer

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Lymphocytes from eight patients with Hodgkin's disease were incubated with phytohemagglutinin (PHA) or pokeweed mitogen (PWM) over 7 days. Thymidine incorporation into DNA and ultrastructural features of transformed cells were studied. Response to these mitogens was either normal or diminished and/or delayed. In seven patients lymphocyte response to PHA was paralleled by a corresponding response to PWM. PHA‐transformed lymphocytes showed fine structural features similar to transformed normal cells. After PWM stimulation, blast cells and plasmacytoid cells in various stages of differentiation were observed. The number of transformed cells corresponded to the magnitude of thymidine incorporation and in cultures with normal PWM response, plasmacytoid cells occurred with almost normal frequency. If the specificity of the mitogens is as postulated, then patients with Hodgkin's disease do not have a selective loss of T lymphocytes. Furthermore, the findings suggest that in some patients there may be a functional impairment of both T and B lymphocytes.

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Activity and isoenzymes of acid phosphatase in human B-cell lymphomas of low-grade malignancy: A novel aid in the classification of malignant lymphoma

Schmidt

Radzun

Schwarze

et al. 1980

Cancer

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Activity and isoelectric focusing (IEF) pattern of lysosomal acid phosphatase (E.C.3.1.3.2.) were investigated in 55 cases of low-grade malignant B-cell lymphoma, classified as chronic B-lymphocytic leukemia (B-CLL), centroblastidcentrocytic follicular lymphoma (CB/CC), lymphoplasmacytic/lympho-plasmacytoid lymphoma (Immunocytoma, IC), and plasmacytoma (PC), applying the criteria of the Kiel classification. The results show (1) that the four lymphoma types present a characteristic range of enzyme activity in an increasing order: B-CLL, CB/CC, IC, and PC. B lymphocytes, germinal center cells, and plasmacytes are the main constituents of these lymphomas. This sequence might reflect one possible mode of B-cell transformation into plasmacytes traversing an amplification stage in germinal centers under normal conditions. (2) All cases showed the basic IEF pattern of normal B lymphocytes with 12 bands localized in three regions between pH 6.1 and 3.9. This finding supports the B-cell origin and the close phenotypical relationship among the investigated lymphomas. (3) The IEF patterns of B-CLL and CB/CC did not differ from that of normal B lymphocytes, whereas two additional isoenzymes were encountered in cases of IC and seven in PC; this suggests that the higher enzyme activity of IC and PC is at least partly due to the appearance of "new" isoenzymes. The results support the validity of the underlying classification and indicate the individuality, B-cell origin, and close relationship among the four lymphoma entities investigated.

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Lysosomale Enzyme in Lymphozyten

Cited by 22 publications

References 18 publications

Heterogeneity of 5′-Nucleotidase Activity in Lymphocytes in Chronic Lymphocytic Leukemia

Heterogeneity of 5′-Nucleotidase Activity in Lymphocytes in Chronic Lymphocytic Leukemia

In vitro lymphocyte response to phytohemagglutinin and pokeweed mitogen in Hodgkin's disease

Activity and isoenzymes of acid phosphatase in human B-cell lymphomas of low-grade malignancy: A novel aid in the classification of malignant lymphoma

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