Lysosomal signalling pathways influence heart rhythm, and
regulate atrial function
REBECCA Burton,
Rebecca Capel,
Emily Akerman
et al.
Abstract:In the heart, endogenous nicotinic acid adenine dinucleotide phosphate (NAADP) triggers lysosomal
calcium release to augment sarcoplasmic reticulum (SR) calcium sequestration, producing larger
calcium transients. However, the role of lysosomal calcium signals in pacemaker activity, a distinct
calcium-operated function of the sino-atrial node (SAN) or atria, a distinct calcium-operated function, has not been investigated. Pharmacological or genetic ablation of the NAADP pathway inhibits spontaneous beating r… Show more
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