Lysophospholipids improve skin moisturization by modulating of calcium‐dependent cell differentiation pathway

Yahagi, Shoichi; Koike, Masayuki; Okano, Yasuaki; Hashimoto, Masaki

doi:10.1111/j.1468-2494.2010.00625.x

Cited by 18 publications

(10 citation statements)

References 33 publications

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“…A role for LPA in promoting skin barrier function was also shown using a dry skin mouse model. Our findings are in agreement with, and have significantly extended previous findings on, a role for LPA in promoting skin moisture (Yahagi et al, 2011).…”

Section: Discussionsupporting

confidence: 93%

LPA Induces Keratinocyte Differentiation and Promotes Skin Barrier Function through the LPAR1/LPAR5-RHO-ROCK-SRF Axis

Sumitomo

Siriwach

Thumkeo

et al. 2019

Journal of Investigative Dermatology

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The skin barrier protects the body from water loss, allergens, and pathogens. Profilaggrin is produced by differentiated keratinocytes and is processed into filaggrin monomers. These monomers cross-link keratin filaments and are also decomposed to natural moisturizing factors in the stratum corneum for skin hydration and barrier function. Deficits in FLG expression impair skin barrier function and underlie skin diseases such as dry skin and atopic dermatitis. However, intrinsic factors that regulate FLG expression and their mechanisms of action remain unknown. Here, we show that lysophosphatidic acid induces FLG expression in human keratinocytes via the LPAR1 and LPAR5 receptors and the downstream RHO-ROCK-SRF pathway. Comprehensive gene profiling analysis further showed that lysophosphatidic acid not only induces FLG expression but also facilitates keratinocyte differentiation. Moreover, lysophosphatidic acid treatment significantly up-regulated FLG production in a three-dimensional culture model of human skin and promoted barrier function in mouse skin in vivo. Thus, our work shows a previously unsuspected role for lysophosphatidic acid and its downstream signaling in the maintenance of skin homeostasis, which may serve as a novel therapeutic target for skin barrier dysfunction.

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Section: Discussionsupporting

confidence: 93%

LPA Induces Keratinocyte Differentiation and Promotes Skin Barrier Function through the LPAR1/LPAR5-RHO-ROCK-SRF Axis

Sumitomo

Siriwach

Thumkeo

et al. 2019

Journal of Investigative Dermatology

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“…Cholesterol synthesis is also highly related to the recovery of the permeability barrier function of the skin 42 . Lysophospholipids are among the most important factors in skin barrier function, skin hydration, and skin inflammation 43,44 . We also observed significant preventive effects on erythema formation in only the GTE-supplemented group (Fig.…”

Section: Discussionmentioning

confidence: 99%

Seven-day Green Tea Supplementation Revamps Gut Microbiome and Caecum/Skin Metabolome in Mice from Stress

Jung

Park

et al. 2019

Sci Rep

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Green tea supplementation has beneficial health effects. However, its underlying mechanisms, such as effects on modulating the intestinal microbiome and endogenous metabolome, particularly following short-term supplementation, are largely unclear. We conducted an integrative metabolomics study to evaluate the effects of short-term (7-day) supplementation of green tea extract (GTE) or its components, epigallocatechin gallate, caffeine, and theanine, on the caecum microbiota and caecum/skin metabolome in mice. Further, we established an integrative metabolome-microbiome model for correlating gut and skin findings. The effects of short-term supplementation with dietary compounds were evaluated with respect to UV stress response, with GTE showing the most remarkable effects. Biplot analysis revealed that Bifidobacteria and Lactobacillus spp. were considerably influenced by short-term GTE supplementation, while Clostridium butyricum was significantly increased by UV stress without supplementation. GTE supplementation helped the skin metabolome defend against UV stress. Interestingly, a significant positive correlation was observed between caecum bacteria (Bifidobacteria, Lactobacillus spp.) and metabolites including skin barrier function-related skin metabolites, caecal fatty acids, and caecal amino acids. Overall, 7-day GTE supplementation was sufficient to alter the gut microbiota and endogenous caecum/skin metabolome, with positive effects on UV stress response, providing insight into the mechanism of the prebiotic effects of GTE supplementation.

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“…LPLs have also industrial and pharmaceutical uses such as emulsifiers and wetting agents for the food-processing (Kasinos et al, 2014) and cosmetic industries (Yahagi et al, 2011), components of liposomes for use in drug delivery (Koklic and Trancar, 2012) and adjuvant in vaccines (Cmielewski et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Lipase-catalyzed production of lysophospholipids

Mnasri

Hérault

Gauvry

et al. 2017

OCL

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-Lysophospholipids, such as lysophosphatidic acid or lysophosphatidylcholine, are important bioactive lipids, involved in various normal and pathological cellular processes. They also have industrial and pharmaceutical uses such as emulsifiers or components of drug delivery systems. Lipases, which natural substrates are long chain triacylglycerols, are important biocatalysts for organic synthesis mainly due to their broad substrate specificity and their ability to display high catalytic activity in organic media. This paper describes the various lipase-catalyzed reactions implemented for the production of lysophospholipids. They include hydrolysis or alcoholysis of phospholipids and acylation of the glycerophosphoryl moiety. Special emphasis is made on our work dealing with the production of lysophospholipids rich in dososahexaenoic acid, an important dietary polyunsaturated fatty acid via the hydrolysis of phospholipids extracted from the microalga Isochrysis galbana.Keywords: lipase / lysophospholipid / hydrolysis / esterification / docosahexaenoic acid Résumé -Synthèse de lysophospholipides catalysée par des lipases. Les lysophospholipides, comme par exemple l'acide lysophosphatidique ou la lysophosphatidylcholine, sont des médiateurs lipidiques impliqués dans de nombreux processus cellulaires. Ils sont également employés au niveau industriel comme émulsifiants ou dans les formulations galéniques, par exemple. Les lipases, dont les substrats naturels sont les triacylglycérols à longues chaînes, sont des biocatalyseurs très utilisés en synthèse organique, du fait de leur large spécificité de substrats et de leur activité catalytique élevée en milieu organique. Cet article décrit les différentes approches développées pour la synthèse des lysophospholipides mettant en oeuvre les lipases, à savoir l'hydrolyse ou l'alcoolyse de phospholipides et l'acylation de la partie glycerophosphoryle correspondant au lysophospholipide recherché. En particulier, nos travaux, portant sur la synthèse de lysophospholipides riches en acide docosahexaénoique par hydrolyse de phospholipides issus de la microalgue Isochrysis galbana, sont présentés.

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Lysophospholipids improve skin moisturization by modulating of calcium‐dependent cell differentiation pathway

Cited by 18 publications

References 33 publications

LPA Induces Keratinocyte Differentiation and Promotes Skin Barrier Function through the LPAR1/LPAR5-RHO-ROCK-SRF Axis

LPA Induces Keratinocyte Differentiation and Promotes Skin Barrier Function through the LPAR1/LPAR5-RHO-ROCK-SRF Axis

Seven-day Green Tea Supplementation Revamps Gut Microbiome and Caecum/Skin Metabolome in Mice from Stress

Lipase-catalyzed production of lysophospholipids

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