Lysophospholipid acyltransferases

Abstract

Despite significant progress in understanding the role of these AGPATs, much is still to be discovered in terms of how each of these AGPATs function in the presence or absence of other AGPATs and what their functional role might be.

Off-Target V(D)J Recombination Drives Lymphomagenesis and Is Escalated by Loss of the Rag2 C Terminus

“…The Pten pathway is evidently an Achilles heel, given that Pten itself is recurrently mutated by cRSS mechanisms here (Fig.1) and in human T-ALL (Mendes et al, 2014). Agpat9 is a 1-acylglycerol-3-phosphate o-acyltransferase involved in the production of phosphatidic acid, a cofactor in the AKT1/Tor pathway (Agarwal, 2012). It remains to be seen whether cRSS-mediated deletions pinpoint new cancer genes, but given the potential applications, this question bears further investigation.…”

AGPAT2 deficiency impairs adipogenic differentiation in primary cultured preadipocytes in a non-autophagy or apoptosis dependent mechanism

“…catalyzes the conversion of lysophosphatidic acid to phosphatidic acid by esterifying the sn-2 position of lysophosphatidic acid [1]. AGPAT2 is involved in the biosynthesis of glycerophospholipids and triacylglycerols and is highly expressed in the adipose tissue, pancreas and liver [2].…”

A two-helix motif positions the lysophosphatidic acid acyltransferase active site for catalysis within the membrane bilayer

“…This large family is not only responsible for phospholipid synthesis, but also for phospholipid re-modeling 4,8,9 . In humans, mutations in AGPAT family members are associated with a number of diseases 10,11 . Sequence analyses of AGPAT family members suggest that they also adopt the acyltransferase αβ protein fold.…”

“…Sequence analyses of AGPAT family members suggest that they also adopt the acyltransferase αβ protein fold. Specifically, they contain four sequence motifs that are conserved in all GPAT structures, which includes the HX 4 D motif at the active site 10,12 .…”