Lysophosphatidic acid induces neurite branch formation through LPA3

Furuta, Daisuke; Yamane, Masayuki; Tsujiuchi, Toshifumi; Moriyama, Ryutaro; Fukushima, Nobuyuki

doi:10.1016/j.mcn.2012.03.006

Cited by 25 publications

(14 citation statements)

References 49 publications

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“…A previous study in murrel showed disruption of brain epinephrine and norepinephrine levels after exposure to carbofuran was localized to the region of the brain regulating behavior and motor activity, suggesting preferential alteration of swimming behaviors [76]. Moreover, neuronal function of LPAR3 has been demonstrated in a previous study; LPA introduced neuronal cells show higher neurite branching through LPAR3 involvement [25]. In the present study, this alteration was shown by the hyperactivity-like behavior exhibited by the mutant fish.…”

Section: Generation Of Lpar3 Knockout Fish By Talensupporting

confidence: 68%

A Novel Function of the Lysophosphatidic Acid Receptor 3 (LPAR3) Gene in Zebrafish on Modulating Anxiety, Circadian Rhythm Locomotor Activity, and Short-Term Memory

Lin

Audira

Malhotra

et al. 2020

IJMS

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Lysophosphatidic acid (LPA) is a small lysophospholipid molecule that activates multiple cellular functions through pathways with G-protein-coupled receptors. So far, six LPA receptors (LPAR1 to LPAR6) have been discovered and each one of them can connect to the downstream cell message-transmitting network. A previous study demonstrated that LPA receptors found in blood-producing stem cells can enhance erythropoietic processes through the activation of LPAR3. In the current study, newly discovered functions of LPAR3 were identified through extensive behavioral tests in lpar3 knockout (KO) zebrafish. It was found that the adult lpar3 KO zebrafish display an abnormal movement orientation and altered exploratory behavior compared to that of the control group in the three-dimensional locomotor and novel tank tests, respectively. Furthermore, consistent with those results, in the circadian rhythm locomotor activity test, the lpar3 KO zebrafish showed a lower level of angular velocity and average speed during the light cycles, indicating an hyperactivity-like behavior. In addition, the mutant fish also exhibited considerably higher locomotor activity during the dark cycle. Supporting those findings, this phenomenon was also displayed in the lpar3 KO zebrafish larvae. Furthermore, several important behavior alterations were also observed in the adult lpar3 KO fish, including a lower degree of aggression, less interest in conspecific social interaction, and looser shoal formation. However, there was no significant difference regarding the predator avoidance behavior between the mutant and the control fish. In addition, lpar3 KO zebrafish displayed memory deficiency in the passive avoidance test. These in vivo results support for the first time that the lpar3 gene plays a novel role in modulating behaviors of anxiety, aggression, social interaction, circadian rhythm locomotor activity, and memory retention in zebrafish.

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Section: Generation Of Lpar3 Knockout Fish By Talensupporting

confidence: 68%

A Novel Function of the Lysophosphatidic Acid Receptor 3 (LPAR3) Gene in Zebrafish on Modulating Anxiety, Circadian Rhythm Locomotor Activity, and Short-Term Memory

Lin

Audira

Malhotra

et al. 2020

IJMS

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“…More recently, transient receptor potential channel, subfamily M, member 2 (TRPM2) was reported to mediate LPA-induced neurite retraction in the developing brain (Jang et al, 2014). Finally, neurite branching, an important process for neuronal network formation, was induced through the introduction of LPA 3 and the addition of LPA into hippocampal cell cultures (Furuta et al, 2012). This physiological response was initiated through G q and the Rho family GTPase 2 (Rnd2) (Furuta et al, 2012).…”

Section: Lparsmentioning

confidence: 99%

“…Finally, neurite branching, an important process for neuronal network formation, was induced through the introduction of LPA 3 and the addition of LPA into hippocampal cell cultures (Furuta et al, 2012). This physiological response was initiated through G q and the Rho family GTPase 2 (Rnd2) (Furuta et al, 2012). …”

Section: Lparsmentioning

confidence: 99%

Lysophosphatidic Acid Signaling in the Nervous System

Yung

Stoddard

Mirendil

et al. 2015

Neuron

217

177

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Summary The brain is composed of many lipids with varied forms that serve not only as structural components but also as essential signaling molecules. Lysophosphatidic acid (LPA) is an important bioactive lipid species that is part of the lysophospholipid (LP) family. LPA is primarily derived from membrane phospholipids and signals through six cognate G protein-coupled receptors (GPCRs), LPA1-6. These receptors are expressed on most cell types within central and peripheral nervous tissues and have been functionally linked to many neural processes and pathways. This review covers a current understanding of LPA signaling in the nervous system, with particular focus on the relevance of LPA to both physiological and diseased states.

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“…Six LPA receptors (LPARs) have been identified : LPA1-LPA6, with genes named LPAR1-LPAR6 (human) and Lpar1-Lpar6 (non-human; Kihara et al, 2014;Yung et al, 2014Yung et al, , 2015. LPARs have been found to function in neurogenesis and brain development (Castilla-Ortega et al, 2011), neurodifferentiation (Fukushima et al, 2002b;Spohr et al, 2008), neural network formation and morphogenesis (Furuta et al, 2012;Roza et al, 2019), neuroplasticity (Fujiwara et al, 2003;Rhee et al, 2006) and glia cell modulation (Shano et al, 2008;Awada et al, 2014).…”

Section: G-coupled Protein Receptors (Gpcrs) Of Lpa and S1p In The Cementioning

confidence: 99%

Lysophospholipids and Their G-Coupled Protein Signaling in Alzheimer’s Disease: From Physiological Performance to Pathological Impairment

Hao

Guo

Feng

et al. 2020

Front. Mol. Neurosci.

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Lysophospholipids (LPLs) are bioactive signaling lipids that are generated from phospholipase-mediated hydrolyzation of membrane phospholipids (PLs) and sphingolipids (SLs). Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are two of the best-characterized LPLs which mediate a variety of cellular physiological responses via specific G-protein coupled receptor (GPCR) mediated signaling pathways. Considerable evidence now demonstrates the crucial role of LPA and S1P in neurodegenerative diseases, especially in Alzheimer's disease (AD). Dysfunction of LPA and S1P metabolism can lead to aberrant accumulation of amyloid-β (Aβ) peptides, the formation of neurofibrillary tangles (NFTs), neuroinflammation and ultimately neuronal death. Summarizing LPA and S1P signaling profile may aid in profound health and pathological processes. In the current review, we will introduce the metabolism as well as the physiological roles of LPA and S1P in maintaining the normal functions of the nervous system. Given these pivotal functions, we will further discuss the role of dysregulation of LPA and S1P in promoting AD pathogenesis.

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Lysophosphatidic acid induces neurite branch formation through LPA3

Cited by 25 publications

References 49 publications

A Novel Function of the Lysophosphatidic Acid Receptor 3 (LPAR3) Gene in Zebrafish on Modulating Anxiety, Circadian Rhythm Locomotor Activity, and Short-Term Memory

A Novel Function of the Lysophosphatidic Acid Receptor 3 (LPAR3) Gene in Zebrafish on Modulating Anxiety, Circadian Rhythm Locomotor Activity, and Short-Term Memory

Lysophosphatidic Acid Signaling in the Nervous System

Lysophospholipids and Their G-Coupled Protein Signaling in Alzheimer’s Disease: From Physiological Performance to Pathological Impairment

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