Lyso-Gb3 modulates the gut microbiota and decreases butyrate production

Aguilera-Correa, John Jairo; Madrazo-Clemente, Patricia; Martínez-Cuesta, M. Carmen; Peláez, Carmen; Ortíz, Alberto; Esteban, Jaime; Requena, Teresa

doi:10.1038/s41598-019-48426-4

Cited by 27 publications

(32 citation statements)

References 84 publications

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“…It is speculated that the striking reduction of butyrate releases the break on histone deacetylase inhibition, allowing for increased inflammation. Concomitantly this may trigger induction of GB3 synthase, thus more lyso-GB3 formation, and may worsen kidney disease and heart disease [ 83 ].…”

Section: Globotriaosylsphingosine/lyso-gb3 (Fabry Disease)mentioning

confidence: 99%

Lyso-glycosphingolipids: presence and consequences

Eijk

Ferraz

Boot

et al. 2020

Essays in Biochemistry

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Lyso-glycosphingolipids are generated in excess in glycosphingolipid storage disorders. In the course of these pathologies glycosylated sphingolipid species accumulate within lysosomes due to flaws in the respective lipid degrading machinery. Deacylation of accumulating glycosphingolipids drives the formation of lyso-glycosphingolipids. In lysosomal storage diseases such as Gaucher Disease, Fabry Disease, Krabbe disease, GM1 -and GM2 gangliosidosis, Niemann Pick type C and Metachromatic leukodystrophy massive intra-lysosomal glycosphingolipid accumulation occurs. The lysosomal enzyme acid ceramidase generates the deacylated lyso-glycosphingolipid species. This review discusses how the various lyso-glycosphingolipids are synthesized, how they may contribute to abnormal immunity in glycosphingolipid storing lysosomal diseases and what therapeutic opportunities exist.

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Section: Globotriaosylsphingosine/lyso-gb3 (Fabry Disease)mentioning

confidence: 99%

Lyso-glycosphingolipids: presence and consequences

Eijk

Ferraz

Boot

et al. 2020

Essays in Biochemistry

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“…Although there is little information on microbiota and chronodisruption in CKD, both obesity and metabolic syndrome increase the risk of CKD. Conversely, CKD has been associated with altered microbiota patterns and metabolites accumulated in CKD may modulate the gut microbiota and butyrate production [62][63][64].…”

Section: Dietary Cluesmentioning

confidence: 99%

Chronodisruption: A Poorly Recognized Feature of CKD

Carriazo

Ramos

Sanz

et al. 2020

Toxins

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Multiple physiological variables change over time in a predictable and repetitive manner, guided by molecular clocks that respond to external and internal clues and are coordinated by a central clock. The kidney is the site of one of the most active peripheral clocks. Biological rhythms, of which the best known are circadian rhythms, are required for normal physiology of the kidneys and other organs. Chronodisruption refers to the chronic disruption of circadian rhythms leading to disease. While there is evidence that circadian rhythms may be altered in kidney disease and that altered circadian rhythms may accelerate chronic kidney disease (CKD) progression, there is no comprehensive review on chronodisruption and chronodisruptors in CKD and its manifestations. Indeed, the term chronodisruption has been rarely applied to CKD despite chronodisruptors being potential therapeutic targets in CKD patients. We now discuss evidence for chronodisruption in CKD and the impact of chronodisruption on CKD manifestations, identify potential chronodisruptors, some of them uremic toxins, and their therapeutic implications, and discuss current unanswered questions on this topic.

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“…A remarkable decrease in butyrate production of gut microbiota is usually associated with certain functional disorders. For example, Fabry disease is often attributed to the accumulation of globotriaosylsphingosine (lyso-Gb3) which alters the formation of SCFAs, resulting in a significant reduction in butyrate concentration [53]. The present study recorded the significant highest fecal butyrate concentration ( P < 0.05) in FCRPG, and the second highest value ( P < 0.05) was observed in CRPG, which means that dietary supplemented with FCRP or CRP can evidently increase epithelial energy supply and maintain normal celluar proliferation and differentiation.…”

Section: Discussionmentioning

confidence: 99%

Dietary supplementation with products of Citrus reticulata "Chachi" for improving the fecal microbiome of weaned piglets

Lin¹,

Li²,

Wang³

et al. 2020

Preprint

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23Nutritional interventions play a critical role in modifying the intestinal microbiome of 24 host animals. This study was conducted to interrogate the physiological effects on 2 25 fecal microflora of weaned piglets via the dietary supplemented with two types of 26 products of Citrus reticulata "Chachi", respectively. For this purpose, A total of 72 27 piglets with uniform sizes were randomly assigned to four dietary treatment groups 28 consisted of a negative control group (NCG), a fermented citrus reticulata "Chachi" 29 pulp group (FCRPG), a Citri Reticulatae Pericarpium group (CRPG) and a positive 30 control group (PCG) in a 21-day feeding trial. After the raising experiment, fresh 31 feces of piglets were analyzed systematically using multi-omics technologies. 32Metagenomics method with high-throughput compositional characterization indicated 33 that the architecture and diversity of fecal microbiome were both influenced by these 34 two additives and compound antibiotics. Metabolite analysis showed that FCRPG 35 have an significant effects on fecal short-chain fatty acids (SCFAs) among four 36 treatment groups. Results of functional proteomics approaches found that FCRPG 37 presented the highest butyrate metabolic level, and CRPG showed the highest flavone 38 and flavonol biosynthesis level in feces. In addition, NCP produced an effective effect 39 on adjusting fecal microbiota profile. Consequently, our findings demonstrate that 40 dietary supplementation with FCRP or CRP modulates the microbial taxa, metabolic 41 and proteomic alterations in fecal microbiota of weaned piglets for health 42 maintaining.43 44 3 48 metabolism, immune regulation and gene expression. The vast majority of commensal 49 micro-bacteria are well adapted to the host environment but also can be shaped by 50 various factors such as nutrient import and external circumstances [2, 3]. Weanling 51 period is a special developmental stage throughout the entire lifecycle of pig, during 52 which piglets have exhibited rapid growth, high demand for nutrition, fast energy 53 harvesting capability [4], and succession of gut microbial composition [5-7]. However, 54 common diseases such as digestive disorders and intestinal inflammation, often 55 plague the piglet farming during this rearing phase. Gut microbiota obviously play the 56 function of facilitating adaption of weanling piglets to fibrous ingredients and 57 reducing the risk of colonization of enteric pathogens after weaning [8]. Actually, 58 although antibiotics have been pervasively applied many decades for antimicrobial 59 application and growth promoting for livetocks in China, European Union has banned 60 their prophylactic use in modern swine industry for the potential public hazard of 61 bacterial resistances and drug residues since 2006 [9, 10]. Thus, nutritional strategies 62 have been employed as an efficient way to improve intestinal microbiota architecture 63 for the purpose of restricting the use of antibiotics and enhancing the health of piglets 64 except for alternative ...

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Lyso-Gb3 modulates the gut microbiota and decreases butyrate production

Cited by 27 publications

References 84 publications

Lyso-glycosphingolipids: presence and consequences

Lyso-glycosphingolipids: presence and consequences

Chronodisruption: A Poorly Recognized Feature of CKD

Dietary supplementation with products of Citrus reticulata "Chachi" for improving the fecal microbiome of weaned piglets

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