Lysine-specific demethylase 3A is important for autophagic occurrence

Regulation of autophagy by protein methylation and acetylation in cancer

“…In contrast, an H3K9me2 demethylase, KDM3A, was shown to act as a coactivator of autophagy-related and lysosomal genes under glucose or amino acid starvation (J. Kim et al, 2020). A starvationdependent increase of KDM3A leads to the specific recruitment of KDM3A to H3K9me2 at the target gene promoter.…”

“…Mammalian FOXO Transcriptional activation of autophagy and lysosomal genes (J. Kim et al, 2020) Non-histone acetylation EP300 ATG5, ATG7, ATG8, and ATG12 Inhibition of starvation-induced autophagy (Lee & Finkel, 2009) VPS34 (K29, K771, and K781) Blockade of VPS34-Beclin1 and VPS34-PI interactions (Su et al, 2017) Raptor (K1097) mTOR activation (Son et al, 2020) Esa1 ATG3 (K19, K48, and K183) K19-K48 acetylation of ATG3 is crucial for autophagy regulation, and K183 is necessary for the E2-like function of ATG3 (Yi et al, 2012) TIP60 ULK1 Autophagy activation (Lin et al, 2012) CREBBP/CBP STX17 (K219 and K223) Inhibition of autophagosome maturation (Shen et al, 2020) FOXO1 (K242, K245, and K262) Inhibition of FOXO1-dependent transcriptional regulation in lung and colorectal cancer cells (Hariharan et al, 2010), (Matsuzaki et al, 2005) GCN5 TFEB (K116, K274, and K279) Inhibition of TFEB dimerization and recruitment to its target gene promoter (Y. Wang et al, 2020) Non-histone deacetylation SIRT1 ATG5, ATG7, and ATG8 Autophagy activation (Lee et al, 2008) LC3 (K49 and K51) Autophagy activation (Huang et al, 2015) FOXO1 Autophagy activation via increased expression of Rab7 (Contreras et al, 2013) proteins act as transcription factors, and certain FOXO members have been identified as autophagy inducers.…”

“…Indeed, combined treatment with BIX‐01294 and kaempferol showed a synergistic effect and prompted autophagic cell death in gastric cancer cells (T. W. Kim et al, 2018). In contrast, an H3K9me2 demethylase, KDM3A, was shown to act as a coactivator of autophagy‐related and lysosomal genes under glucose or amino acid starvation (J. Kim et al, 2020). A starvation‐dependent increase of KDM3A leads to the specific recruitment of KDM3A to H3K9me2 at the target gene promoter.…”