Lysine-specific demethylase 1 (LSD1) serves as an potential epigenetic determinant to regulate inflammatory responses in mastitis

Wang, Jingjing; Z, Wu; Zhu, Xiongwei; Li, Peixuan; Fu, Yiwu; Wang, Xia; Sun, Yuena; Zhou, Ershun; Yang, Zhengtao

doi:10.1016/j.intimp.2020.107324

Cited by 10 publications

(6 citation statements)

References 30 publications

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“…In Escherichia coli –induced mastitis mice, E. coli infection leads to histone hyperacetylation (H3K14 and H4K8) at the promoter of immune genes ( 8 ). Moreover, we previously showed that lysine-specific demethylase 1 (LSD1) is a potential epigenetic determinant to regulate inflammatory responses in mastitis ( 9 ). Here, we focused on the epigenetic regulation of another histone demethylase, Jumonji domain-containing 3 (JMJD3), in LPS-induced mastitis.…”

mentioning

confidence: 99%

The JMJD3 histone demethylase inhibitor GSK-J1 ameliorates lipopolysaccharide-induced inflammation in a mastitis model

Wang

Xian

et al. 2022

Journal of Biological Chemistry

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confidence: 99%

The JMJD3 histone demethylase inhibitor GSK-J1 ameliorates lipopolysaccharide-induced inflammation in a mastitis model

Wang

Xian

et al. 2022

Journal of Biological Chemistry

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“…In this study, hPDLSCs were separated and treated by LPS to simulate inflammatory microenvironment, after which we found that LSD1 expression was activated, which was coupled with increased content of TNF‐α and declined content of IL‐10. Extensive literature suggested that LSD1 expression was upregulated in injured tissues induced by LPS (Jingjing et al, 2021; Tokarz et al, 2019). In inflammatory microenvironment where LSD1 was recruited, expressions of inflammatory cytokines were activated while LSD1 knockdown resulted in blocked inflammatory reaction (Oh et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Effect of LSD1 on osteogenic differentiation of human periodontal ligament stem cells in periodontitis

et al. 2021

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Periodontitis is defined as a pathophysiological damage and is manifested with even deficiency of periodontal membranes, alveolar bones, and teeth, which is the consequence of the crosstalk among particular bacterial pathogen, perilous immune reaction, and proactive herpesviruses (Slots, 2017). Exact etiology and pathogenesis of periodontitis include aging, excessive smoking, systemic diseases (diabetes, cardiovascular disorders, and other distal organ conditions), insufficient oral care, and inappropriate chewing way (Eke et al., 2016).Periodontitis is associated with destructive tooth function, affected esthetics, low self-esteem, complicated systemic dilemma, and degraded living quality (Fischer et al., 2020). One of the most prominent traits of periodontitis is the accumulation of periodontitis-related bacteria, accompanied with inflammatory reaction at the subgingival site and immigration of bacteria out of the mouth cavity to induce extraoral health problems and even cancer related to periodontium (Hoare et al., 2019). Although surgery, cigarette cessation, oral hygiene

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“…Similarly, GSK-J1 suppressed KDM6B and therefore decreased the expression of inflammatory cytokines TNF-α, IL-1β and IL6. KDM1A was also a key pro-inflammatory regulator of mastitis, as demonstrated by Wang et al [ 153 ] These authors had found that a KDM1A inhibitor (GSK-KDM1A) could up-regulate histone H3K4me2 and H3K9me2, which inhibited the NF-κB signaling pathway to reduce the expression of inflammatory factors including TNF-α, IL-6, and IL-8, thus reducing the inflammatory reaction in mammary epithelial cells.…”

Section: Kdms and Inflammatory Diseasesmentioning

confidence: 99%

Histone demethylases in the regulation of immunity and inflammation

Yin

Zhao

et al. 2023

Cell Death Discov.

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Pathogens or danger signals trigger the immune response. Moderate immune response activation removes pathogens and avoids excessive inflammation and tissue damage. Histone demethylases (KDMs) regulate gene expression and play essential roles in numerous physiological processes by removing methyl groups from lysine residues on target proteins. Abnormal expression of KDMs is closely associated with the pathogenesis of various inflammatory diseases such as liver fibrosis, lung injury, and autoimmune diseases. Despite becoming exciting targets for diagnosing and treating these diseases, the role of these enzymes in the regulation of immune and inflammatory response is still unclear. Here, we review the underlying mechanisms through which KDMs regulate immune-related pathways and inflammatory responses. In addition, we also discuss the future applications of KDMs inhibitors in immune and inflammatory diseases.

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Lysine-specific demethylase 1 (LSD1) serves as an potential epigenetic determinant to regulate inflammatory responses in mastitis

Cited by 10 publications

References 30 publications

The JMJD3 histone demethylase inhibitor GSK-J1 ameliorates lipopolysaccharide-induced inflammation in a mastitis model

The JMJD3 histone demethylase inhibitor GSK-J1 ameliorates lipopolysaccharide-induced inflammation in a mastitis model

Effect of LSD1 on osteogenic differentiation of human periodontal ligament stem cells in periodontitis

Histone demethylases in the regulation of immunity and inflammation

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