Lysine specific demethylase 1 inhibitor alleviated lipopolysaccharide/D-galactosamine-induced acute liver injury

Wang, Xia; Sun, Yuena; Fu, Yiwu; Wu, Hanpeng; Chen, Yi‐Chun; Ye, Yingrong; Zhou, Qingqing; Li, He; Zhou, Ershun; Wang, Jingjing; Yang, Zhengtao

doi:10.1016/j.ejphar.2022.175227

Cited by 2 publications

(1 citation statement)

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“…Demethylation of different sites could lead to different effects, including the inhibition or activation of target genes [ 9 ]. Interestingly, abnormal histone demethylation levels are closely associated with various inflammatory diseases, including kidney injury, liver injury, and autoimmune diseases [ 10 , 11 ]. Increasing evidence had revealed that this modification controls cell development and regulates immune pathways [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Histone demethylases in the regulation of immunity and inflammation

Yin

Zhao

et al. 2023

Cell Death Discov.

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Pathogens or danger signals trigger the immune response. Moderate immune response activation removes pathogens and avoids excessive inflammation and tissue damage. Histone demethylases (KDMs) regulate gene expression and play essential roles in numerous physiological processes by removing methyl groups from lysine residues on target proteins. Abnormal expression of KDMs is closely associated with the pathogenesis of various inflammatory diseases such as liver fibrosis, lung injury, and autoimmune diseases. Despite becoming exciting targets for diagnosing and treating these diseases, the role of these enzymes in the regulation of immune and inflammatory response is still unclear. Here, we review the underlying mechanisms through which KDMs regulate immune-related pathways and inflammatory responses. In addition, we also discuss the future applications of KDMs inhibitors in immune and inflammatory diseases.

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