Lysine-Rich Polypeptide Modulates Forkhead Box O3 and Phosphoinositide 3-Kinase-Protein Kinase B Pathway To Induce Apoptosis in Breast Cancer
Sanjeevram Dhandapani,
Han-Sol Choi,
Hoyong Chung
et al.
Abstract:The
PI3K/AKT/FOXO3 pathway is one of the most frequently
involved
signaling pathways in cancer, including breast cancer. Therefore,
we synthesized a novel lysine-rich polypeptide (Lys-PP) using de novo assembly method and evaluated its anticancer effect.
We characterized the structural and physicochemical properties of
Lys-PP using various techniques. Later, we used integrated approaches
such as in silico, in vitro, and in vivo analysis to confirm the anticancer and therapeutic
effect of Lys-PP. First, RNA seq… Show more
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