Lysine requirements of healthy adult Indian subjects receiving long-term feeding, measured with a 24-h indicator amino acid oxidation and balance technique

Kurpad, Anura V; Regan, Meredith M.; Raj, Tony; El-Khoury, Antoine E.; Kuriyan, Rebecca; Vaz, Mário; Chandakudlu, Deepak; Venkataswamy, Veena G; Borgonha, Sudhir; Young, Vernon R.

doi:10.1093/ajcn/76.2.404

Cited by 53 publications

(40 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…140: 54-59, 2010. sickkids.ca. 9 Abbreviations used: IAA, indispensable amino acid; IAAB, indicator amino acid balance; IAAO, indicator amino acid oxidation; REE, resting energy expenditure; UNU, United Nations University; VCO 2 , rate of CO 2 production.…”

mentioning

confidence: 99%

Lysine Requirement of Healthy, School-Aged Indian Children Determined by the Indicator Amino Acid Oxidation Technique

Pillai

Elango

Muthayya

et al. 2010

The Journal of Nutrition

View full text Add to dashboard Cite

We recently reported the lysine requirement of school-aged children living in Canada consuming a mixed diet to be 35 mg.kg(-1).d(-1). Because the majority of children in the world live on cereal-based diets in developing countries, we measured the daily lysine requirement in healthy children living in India and consuming a mostly cereal-based diet. Our objective in this study was to determine the lysine requirement in healthy, school-aged children in the developing world by using the indicator amino acid oxidation method with l-[1-(13)C] phenylalanine. Six healthy, school-aged children consumed 7 levels of lysine (5, 15, 25, 35, 50, 65, and 80 mg.kg(-1).d(-1)) each in a random order along with an amino acid mixture providing energy and protein intakes of 1.7 x resting energy expenditure and 1.5 g.kg(-1).d(-1), respectively. The mean lysine requirement was determined by applying a 2-phase linear regression crossover analysis on tracer oxidation (F(13)CO(2)) data, which identified a breakpoint (requirement) at minimal F(13)CO(2) in response to the graded lysine intakes. The mean lysine requirements with the upper 95% CI for children were determined to be 33.5 and 46.6 mg.kg(-1).d(-1), respectively, by breakpoint analysis of the F(13)CO(2) data. The mean lysine requirements of Indian children were almost identical to that of Canadian children (35 mg.kg(-1).d(-1)). There is no evidence for any adaptation in lysine requirements in children from developing countries such as India.

show abstract

mentioning

confidence: 99%

Lysine Requirement of Healthy, School-Aged Indian Children Determined by the Indicator Amino Acid Oxidation Technique

Pillai

Elango

Muthayya

et al. 2010

The Journal of Nutrition

View full text Add to dashboard Cite

show abstract

“…The risk of lysine inadequacy is high where low socioeconomic groups depend on wheat for their protein supply (1), but experimental evidence of the nutritional benefits of increasing the lysine content of wheat flour is limited (2)(3)(4)(5)(6)(7)(8). This study, which was a part of a larger wheat fortification trial, was based on a hypothesis that fortification of a lysine inadequate diet in poor communities may reduce anxiety and improve stress response, thereby potentially improving the quality of life.…”

mentioning

confidence: 99%

Lysine fortification reduces anxiety and lessens stress in family members in economically weak communities in Northwest Syria

Smriga

Ghosh

Mouneimne

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Lysine is a limiting amino acid in diets based on wheat as the staple. In experimental animals, prolonged dietary lysine inadequacy increases stress-induced anxiety. If observed in humans, such a result would have a strong implication for the relationship between nutrition and communal quality of life and mental health. As part of a 3-month randomized double-blind study, we tested whether lysine fortification of wheat reduces anxiety and stress response in family members in poor Syrian communities consuming wheat as a staple food. In the lysine-fortified group, the plasma cortisol response to the blood drawing as a cause of stress was reduced in females, as was sympathetic arousal in males as measured by skin conductance. Lysine fortification also significantly reduced chronic anxiety as measured by the trait anxiety inventory in males. These results suggest that some stress responses in economically weak populations consuming cereal-based diets can be improved with lysine fortification.

show abstract

“…Well nourished Indians showed a trend toward improved muscle function with higher lysine intakes. There are several lines of reasoning to suggest that lysine intake may influence muscle function (Kurpad et al, 2002). High-protein, low-carbohydrate diets have also been investigated for treatment of type 2 diabetes with positive effects on glycemic regulation, including postprandial glucose and insulin responses, reducing fasting blood glucose and the percentage of glycated hemoglobin.…”

Section: Role Of Proteins In Alleviating the Symptoms Of Metabolic Symentioning

confidence: 99%

Interplay between proteins and metabolic syndrome–A review

Miglani

Bains

2017

Critical Reviews in Food Science and Nutrition

View full text Add to dashboard Cite

Metabolic syndrome is characterized by hypertension; hyperglycemia; hypertriglyceridemia; reduced high-density lipoprotein cholesterol levels and abdominal obesity. Abundant data suggest that, compared with other people, patients meeting these diagnostic criteria have a greater risk of having substantial clinical consequences, the two most prominent of which are the development of diabetes mellitus and coronary heart disease. The metabolic syndrome is a health issue of epidemic proportions. Its prevalence in the world continues to increase, hand in hand with that of obesity. Protein, on the other hand, is the foundation of cell-building, especially in muscle tissue. The body needs protein to build not only muscle cells, but the cells of major organs, skin and red blood cells. For people with metabolic syndrome, one of the other functions of protein is to slow down the absorption of carbohydrates. When proteins are consumed with carbohydrates, it takes longer for the digestive system to break down that meal. This means that the sugar created from those carbohydrates is released at a slower rate, preventing spikes in both blood sugar and insulin. As the understanding of the metabolic syndrome evolves, it is likely that more comprehensive therapeutic options will become available.

show abstract

Lysine requirements of healthy adult Indian subjects receiving long-term feeding, measured with a 24-h indicator amino acid oxidation and balance technique

Abstract: Full adaptation to a low lysine intake occurs within 7 d. The previously proposed tentative mean lysine requirement for Western subjects of 30 mg x kg(-1) x d(-1) is confirmed for healthy Indian adults.

Cited by 53 publications

References 30 publications

Lysine Requirement of Healthy, School-Aged Indian Children Determined by the Indicator Amino Acid Oxidation Technique

Lysine Requirement of Healthy, School-Aged Indian Children Determined by the Indicator Amino Acid Oxidation Technique

Lysine fortification reduces anxiety and lessens stress in family members in economically weak communities in Northwest Syria

Interplay between proteins and metabolic syndrome–A review

Contact Info

Product

Resources

About