Lysine metabolism is a novel metabolic tumor suppressor pathway in breast cancer

Wu, Jianchun; Kramer, Kaitrin; Crowe, David L.

doi:10.1038/s41388-023-02766-8

Cited by 4 publications

(1 citation statement)

References 44 publications

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“…Understanding the intricate mechanisms by which lysine operates in cancer patients provides opportunities for targeted therapeutic interventions. Manipulating lysine availability, targeting lysine-related metabolic pathways, or considering lysine as an immunomodulatory factor may hold promise for optimizing treatment strategies and improving patient outcomes in cancer (30). The roles of lysine-metabolizing proteins in AML provide insights into disease biology and potential therapeutic targets.…”

Section: Lysine Deprivationmentioning

confidence: 99%

Exploiting leucine metabolism for therapeutic benefit in acute Myeloid Leukemia

Md Rakibul Hasan,

Johnathon Hall,

Faisal Ahmed

2024

GSC Adv. Res. Rev.

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Acute Myeloid Leukemia (AML) presents significant challenges in treatment, especially for elderly patients. Conventional therapies have limitations, necessitating the exploration of novel strategies. Metabolic reprogramming in cancer cells offers promise in this regard, with growing evidence pointing to dysregulated leucine metabolism in AML. Leucine deprivation has shown potential in inhibiting leukemic cell proliferation, inducing cell cycle arrest, and enhancing differentiation. Combination therapies involving leucine deprivation and chemotherapy have exhibited synergistic effects. The precise molecular mechanisms of leucine deprivation's anti-leukemic effects, particularly its potential impact on the mTOR signaling pathway, require further elucidation. Targeting BCAAs and other amino acids, such as methionine and lysine, holds promise in disrupting leukemia cell proliferation and promoting apoptosis. These findings underscore the potential of exploiting leucine metabolism and amino acid pathways for therapeutic benefits in AML.

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Section: Lysine Deprivationmentioning

confidence: 99%

Exploiting leucine metabolism for therapeutic benefit in acute Myeloid Leukemia

Md Rakibul Hasan,

Johnathon Hall,

Faisal Ahmed

2024

GSC Adv. Res. Rev.

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Identification of mitochondria-related genes as diagnostic biomarkers for diabetic nephropathy and their correlation with immune infiltration: New insights from bioinformatics analysis

Yan,

Du,

Huang

et al. 2024

International Immunopharmacology

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Integrative physiology of lysine metabolites

Tan,

Chrysopoulou,

Rinschen

2023

Physiological Genomics

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Lysine is an essential amino acid that serves as a building block in protein synthesis. Beside this, lysine's metabolic activity has only recently been unraveled. Lysine metabolism is tissue specific and is linked to several renal, cardiovascular and endocrinological diseases through human metabolomics datasets. As a free molecule, lysine takes part in antioxidant response, engages in protein modifications and its chemistry shapes both proteome and metabolome. In the proteome, it is an acceptor for a plethora of posttranslational modifications. In the metabolome it can be modified, conjugated and degraded. Here, we provide an update on integrative physiology of mammalian lysine metabolites such as α-aminoadipic acid, saccharopine, pipecolic acid, and lysine conjugates such as acetyl-lysine, and sugar-lysine conjugates such as advanced glycation end products. We also comment on their emerging associative and mechanistic links to renal disease, hypertension, diabetes and cancer.

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Lysine metabolism is a novel metabolic tumor suppressor pathway in breast cancer

Cited by 4 publications

References 44 publications

Exploiting leucine metabolism for therapeutic benefit in acute Myeloid Leukemia

Exploiting leucine metabolism for therapeutic benefit in acute Myeloid Leukemia

Identification of mitochondria-related genes as diagnostic biomarkers for diabetic nephropathy and their correlation with immune infiltration: New insights from bioinformatics analysis

Integrative physiology of lysine metabolites

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