Lysine in Human Nutrition

Jansen, G. Richard

doi:10.1093/jn/76.2_suppl.1

Cited by 39 publications

(17 citation statements)

References 130 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Por sua vez, Jansen (1962) comentou que a hemoglobina contém relativamente alta proporção de lisina (10,1%) e que talvez altos níveis de lisina sejam requeridos para manter altos níveis de hemoglobina. No entanto, Leeson & Summers (1997) comentaram que frangas semipesadas podem ter maiores exigências nutricionais em virtude da maior exigência de mantença em relação às frangas leves.…”

Section: Resultsunclassified

“…Esses resultados confirmam a maior exigência de lisina total para ganho de peso de aves leves (o valor foi 5,43% superior ao das aves semipesadas). A maior exigência nutricional das aves leves provavelmente está relacionada ao seu temperamento mais agitado, o que leva a um comportamento mais ativo e, portanto a maior atividade física em comparação às aves semipesadas, exigindo, assim, maior aporte nutricional (Helander, 1961;Fitts et al, 1976;Jansen, 1962). Entretanto, durante este período experimental as aves foram criadas em gaiolas.…”

Section: Resultsunclassified

See 1 more Smart Citation

Exigência nutricional de lisina para poedeiras leves e semipesadas nos períodos de 1 a 3 e de 4 a 6 semanas de idade

Rodrigueiro¹,

Rostagno²,

Albino³

et al. 2007

R. Bras. Zootec.

View full text Add to dashboard Cite

RESUMO -Com o objetivo de determinar a exigência nutricional de lisina para poedeiras leves e semipesadas em crescimento nos períodos de 1 a 3 e de 4 a 6 semanas de idade, foram utilizadas 480 aves no período de 1 a 3 semanas de idade e 432 aves no período de 4 a 6 semanas de idade. Em ambos os períodos, foram utilizadas aves Hy Line, 50% Hy-line W 36 (leves) e 50% Hy-line Brown (semipesadas), em delineamento inteiramente casualizado, em esquema fatorial 6 × 2, composto de seis níveis de lisina (0,00; 0,06; 0,12; 0,18; 0,24 e 0,30%) e duas linhagens de aves de postura. Considerando os resultados obtidos para as variáveis analisadas, a exigência de lisina total para o período de 1 a 3 semanas de idade foi 1,052% para aves leves e de 0,981% para aves semipesadas ou 207,38 mg de lisina total/dia para aves leves e 198,63 mg de lisina total/dia para aves semipesadas. Para o período de 4 a 6 semanas, a exigência de lisina foi de 0,939% de lisina para aves leves e de 0,889% de lisina para aves semipesadas ou 323,30 mg de lisina total/dia para aves leves e 300,29 mg de lisina total/dia para aves semipesadas. Palavra-chave: aminoácidos, crescimento, exigência lisina, poedeiras comerciaisNutritional requirement of lysine for white-egg and brown-egg laying hens from 1 to 3 and 4 to 6 weeks of age ABSTRACT -With the objective of determine the nutritional requirement of lysine for growing white-egg and brownegg laying hens in the period from 1 to 3 and 4 to 6 weeks of age, 480 birds were used in the period from 1 to 3 weeks of age and 432 birds in the period from 4 to 6 weeks of age. In both periods, Hy-line birds were used; 50% Hy-line W 36 (White) and 50% Hy-line Brown in completely randomized design in a 6 × 2 factorial arrangement (level of lysine [0.00, 0.06, 0.12, 0.18, 0.24, and 0.30%] and strains of laying hens). Based on the obtained results for the analyzed variable, the total lysine requirement for the period from 1 to 3 weeks of age was 1.052% for white birds and 0.981% brown birds or 207.38 mg of total lysine/day for white birds and 198.63 mg of total lysine/day for brown birds. For the period from 4 to 6 weeks of age the lysine requirement was 0.939% for white birds and 0.889% for brown birds or 323.30 mg of total lysine/day for white birds and 300.29 mg of total lysine/day for brown birds.Key Words: amino acids, growth, commercial laying hens, lysine requirement IntroduçãoQuando se busca entender o programa de alimentação de aves para postura de ovos de mesa durante a fase de crescimento, acredita-se que o manejo nutricional seja o ponto crítico, pois as aves leves e semipesadas têm apresentado mudanças na idade à maturidade sexual, que é reduzida em um dia por ano (Leeson & Summers, 1997). Tem-se considerado, portanto, que a chave para o sucesso do manejo nutricional é maximizar o peso corporal das aves durante a fase de crescimento. Desse modo, supõe-se que as aves que atingirem o peso ideal à maturidade sexual apresentarão maior produção e melhor formação da casca de ovos.Geralmente, os programas alimentare...

show abstract

Section: Resultsunclassified

Exigência nutricional de lisina para poedeiras leves e semipesadas nos períodos de 1 a 3 e de 4 a 6 semanas de idade

Rodrigueiro¹,

Rostagno²,

Albino³

et al. 2007

R. Bras. Zootec.

View full text Add to dashboard Cite

show abstract

“…Because from a practical or international perspective (11)(12)(13) it is important to validate our proposed lysine requirements for adults (2,3,14), we also explored the kinetics of whole-body lysine metabolism throughout a continuous 24-h period at defined lysine intakes. Waterlow (15) concluded that although the results of our tracer studies are consistent with an increased requirement for leucine, there is less information about the other indispensable amino acids.…”

Section: Introductionmentioning

confidence: 99%

Twenty-four–hour intravenous and oral tracer studies with L-[1-13C]-2-aminoadipic acid and L-[1-13C]lysine as tracers at generous nitrogen and lysine intakes in healthy adults

El-Khoury¹,

Basile²,

Beaumier³

et al. 1998

The American Journal of Clinical Nutrition

View full text Add to dashboard Cite

show abstract

“…CAA depletion could also compromise IGF-1 production. In fact, it has been observed that in humans, lysine sufficiency increased IGF-1 concentrations (Jansen 1962), and in animals low lysine intakes decreased muscle protein accretion and significantly downregulated hepatic IGFBP-1, as well as muscle GH-R and IGF-II (Ishida et al 2011;Hevry et al 2007). Furthermore, arginine has been demonstrated to stimulate IGF-1 production (Chevalley et al 1998).…”

Section: Discussionmentioning

confidence: 99%

Growth Hormone Deficiency and Lysinuric Protein Intolerance: Case Report and Review of the Literature

et al. 2014

View full text Add to dashboard Cite

Background: Lysinuric protein intolerance (LPI; MIM# 222700) is a rare metabolic disorder caused by a defective cationic amino acids (CAA) membrane transport leading to decreased circulating plasma CAA levels and resulting in dysfunction of the urea cycle. Short stature is commonly observed in children with LPI and has been associated with protein malnutrition. A correlation between LPI and growth hormone deficiency (GHD) has also been postulated because of the known interaction between the AA arginine, ornithine, and lysine and growth hormone (GH) secretion. Our report describes a case of GHD in an LPI patient, who has not presented a significant increase in growth velocity with recombinant-human GH (rhGH) therapy, suggesting some possible pathogenic mechanisms of growth failure.Case Presentation: The proband was a 6-year-old boy, diagnosed as suffering from LPI, erythrophagocytosis (HP) in bone marrow, and short stature. Two GH provocative tests revealed GHD. The patient started rhGH therapy and a controlled-protein diet initially with supplementation of oral arginine and then of citrulline. At 3-year follow-up, no significant increase in growth velocity and in insulin-like growth factor-1 (IGF-1) levels was observed. Inadequate nutrition and low plasmatic levels of arginine, ornithine, lysine, and HP may have contributed to his poor growth. Conclusion:Our case suggests that growth failure in patients with GHD and LPI treated with rhGH could have a complex and multifactorial pathogenesis. Persistently low plasmatic levels of lysine, arginine, and ornithine, associated with dietary protein and caloric restriction and systemic inflammation, could determine a defect in coupling GH to IGF-1 production explaining why GH replacement therapy is not able to significantly improve growth impairment. We hypothesize that a better understanding of growth failure pathophysiology in these patients could lead to the development of more rational strategies to treat short stature in patients with LPI.

show abstract

Lysine in Human Nutrition

Cited by 39 publications

References 130 publications

Exigência nutricional de lisina para poedeiras leves e semipesadas nos períodos de 1 a 3 e de 4 a 6 semanas de idade

Exigência nutricional de lisina para poedeiras leves e semipesadas nos períodos de 1 a 3 e de 4 a 6 semanas de idade

Twenty-four–hour intravenous and oral tracer studies with L-[1-13C]-2-aminoadipic acid and L-[1-13C]lysine as tracers at generous nitrogen and lysine intakes in healthy adults

Growth Hormone Deficiency and Lysinuric Protein Intolerance: Case Report and Review of the Literature

Contact Info

Product

Resources

About