Lyprinol™ only partially improves indicators of small intestinal integrity in a rat model of 5-fluorouracil-induced mucositis

Grape seed extract protects IEC-6 cells from chemotherapy-induced cytotoxicity and improves parameters of small intestinal mucositis in rats with experimentally-induced mucositis.

“…13 Currently, there is a deficiency of effective prophylactic or curative treatments for intestinal mucositis. 15 A number of new strategies have been tested including lyprinol, 16 insulin-like growth factor-I (IGF-I), 17 whey-derived growth factors, 18 keratinocyte growth factor 19 and probiotics. 20 However, these treatments have only been reported to partially prevent intestinal mucositis.…”

Oral ingestion ofStreptococcus thermophilusdoes not affect mucositis severity or tumor progression in the tumor-bearing rat

“…The dark agouti rat represents an ideal model for assessing the effects of different chemotherapy agents on the gut (mucositis) and for utilization of the non-invasive sucrose breath test (SBT). [10][11][12]27 The additional advantage of utilizing this particular strain of rat is that a specific mammary adenocarcinoma can be experimentallyimplanted, 28 thereby allowing further investigation of any putative treatment and its effects in the presence of a tumor. 26,29,30 Thus, this study sought to assess the effects of TH-4 on MTXinduced small intestinal mucositis and tumor progression in tumor-bearing rats.…”

“…Villus blunting and crypt shortening 3,8 are common features of mucositis, leading to decreased disaccharidase activities, 9 resulting in a reduced absorptive capacity. [10][11][12] This increases the risk of complications, as the small intestine is the primary absorptive organ of the body. Not only is the small intestine damaged, but its capacity to renew, repair and regenerate is inhibited due to decreased nutrient absorption.…”

Mucositis and non-invasive markers of small intestinal function

“…46 The SBT has been successfully applied to detect mucositis induced by representative drugs from different classes of chemotherapy agents including MTX, 5-Fluorouracil, cyclophosphamide and etoposide, doxorubicin, etoposide and irinotecan. 67,[70][71][72][73][74][75] More recently, the SBT has been used successfully to monitor small intestinal function with a range of candidate anti-mucositis treatments including oral folinic acid, 70 Streptococcus thermophilus 71 and Lyprinol 75 in the dark agouti rat receiving chemotherapy.…”