Lyotropic Phase Behavior of Poly(ethylene oxide)−Poly(butadiene) Diblock Copolymers: Evolution of the Random Network Morphology

Jain, Sumeet; Dyrdahl, Mitchell H. E.; Gong, Xiaobo; Scriven, L. E.; Bates, Frank S.

doi:10.1021/ma702322b

Cited by 28 publications

(39 citation statements)

References 67 publications

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“…Flory−Huggins parameter (χ) affords an intrinsic thermodynamic driving force for BCP self‐assembly . BCPs with a high χ, and thus a high phase‐segregation ability, can promote self‐assembly.…”

Section: Factors Affecting Bcp Nano‐object Morphologiesmentioning

confidence: 99%

New Insights into RAFT Dispersion Polymerization‐Induced Self‐Assembly: From Monomer Library, Morphological Control, and Stability to Driving Forces

Wang

2018

Macromol. Rapid Commun.

180

138

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Polymerization-induced self-assembly (PISA) has been established as an efficient, robust, and versatile approach to synthesize various block copolymer nano-objects with controlled morphologies, tunable dimensions, and diverse functions. The relatively high concentration and potential scalability makes it a promising technique for industrial production and practical applications of functional polymeric nanoparticles. This feature article outlines recent advances in PISA via reversible addition-fragmentation chain transfer dispersion polymerization. Considerable efforts to understand morphological control, broaden the monomer library, enhance morphological stability, and incorporate multiple driving forces in PISA syntheses are summarized herein. Finally, perspectives on the future of PISA research are discussed.

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Section: Factors Affecting Bcp Nano‐object Morphologiesmentioning

confidence: 99%

New Insights into RAFT Dispersion Polymerization‐Induced Self‐Assembly: From Monomer Library, Morphological Control, and Stability to Driving Forces

Wang

2018

Macromol. Rapid Commun.

180

138

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“…The water was removed by sublimation to eliminate the possibility of surface‐tension‐derived artifacts associated with a traditional drying process. The representative nature of this sample preparation procedure for hydrogel morphology has been discussed elsewhere 22–27. Images were also produced for the third face, the perpendicular face, but the hydrogel was too thin to be mounted in a manner consistent with the fracturing procedure described previously, and these images were not of a quality necessary for subsequent analysis.…”

Section: Testing and Characterizationmentioning

confidence: 99%

Effect of magnetization on the gel structure and protein electrophoresis in polyacrylamide hydrogel nanocomposites

Thompson

Stretz

Arce

et al. 2012

J of Applied Polymer Sci

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In this study, polyacrylamide nanocomposite hydrogels were formulated in combination with sodium montmorillonite (MMT) in the presence of a 2-T magnetic field. This top-down nanomanufacturing approach led to interesting changes in the internal structure of the gel and ultimately to a dramatic improvement in the ability of the composite to separate the two protein probes, ovum serum albumin and carbonic anhydrase. The morphology of the nanocomposite hydrogel was analyzed with cryogenic scanning and transmission electron microscopy, wide-angle X-ray diffraction, and small-angle scattering to determine whether morphological changes would correlate with this improved separation. As the volume fractions of MMT were well under 1% in this study (because of aqueous swelling), scattering data were dominated by the polymer structure. Significant morphological changes were noted at two length scales: (1) the hydrogel cell structure, at hundreds of nanometers, appeared to ex-hibit changes in the anisotropic orientation with magnetization, and (2) the polyamide structure, at tens of nanometers, exhibited decreasing pore size (small-angle Xray scattering). The separation data correlated most closely with a reduction in pore size; however, an additional contribution to separation from local electrostatic effects from the presence of charged MMT in the cell walls could not be discounted. The change in the pore size associated with processing may have been due to the MMT presence altering the diffusion rates of the reactants during polymer formation. The method demonstrated herein could be used ultimately to separate proteins in their native state, with the potential retention of function for downstream applications, such as novel detection techniques or purification.

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“…Most of the published experimental PB‐PEO assembly studies focused mainly on the general morphology as a function of f . The effect of M n and f on PB‐PEO polymersome bilayer thickness, mechanistic properties, detergent response, mixtures of two PB‐PEO polymers, or adhesiveness of functionalized PB‐PEO polymersomes have also been investigated.…”

Section: Introductionmentioning

confidence: 99%

How molecular internal-geometric parameters affect PB-PEO polymersome size in aqueous solution

Habel

Ogbonna²,

Larsen

et al. 2015

J. Polym. Sci. Part B: Polym. Phys.

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Amphiphilic polybutadiene polyethylene oxide (PB‐PEO) is one of the best known chemistries to form stable vesicular morphologies, stated as polymersomes, in aqueous environment. Mimicking cell membranes, these structures self‐assemble in an “amphiphilic window” determined by 0.15 < f < 0.35 where f is the ratio between the hydrophilic block volume and the entire diblock volume. However the polymersome size distribution also depends on molecular weight (Mn) and in order to gain insight on how f and Mn together determine polymersome size, we prepared PB‐PEO diblock copolymers with different block lengths and analyzed vesicle morphology via Dynamic light scattering (DLS) and Freeze‐fracture transmission electron microscopy (FF‐TEM). We found three main regimes: high f / low Mn with polymersomes of mixed diameter, high f / high Mn with mainly large polymersomes and low f, with mainly small polymersomes. In the first region, the polymersomes are highly polydisperse. There is a tendency towards increased diameter with increasing f and Mn. Taken together our findings can help to identify how polymersome self‐assembly can be controlled to achieve size distribution specificity alleviating the need for subsequent tuning of size via extrusion. This can pave the way for cost‐effective upscaling of polymersome production for biomedical and biomimetic applications. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2016, 54, 699–708

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Lyotropic Phase Behavior of Poly(ethylene oxide)−Poly(butadiene) Diblock Copolymers: Evolution of the Random Network Morphology

Cited by 28 publications

References 67 publications

New Insights into RAFT Dispersion Polymerization‐Induced Self‐Assembly: From Monomer Library, Morphological Control, and Stability to Driving Forces

New Insights into RAFT Dispersion Polymerization‐Induced Self‐Assembly: From Monomer Library, Morphological Control, and Stability to Driving Forces

Effect of magnetization on the gel structure and protein electrophoresis in polyacrylamide hydrogel nanocomposites

How molecular internal-geometric parameters affect PB-PEO polymersome size in aqueous solution

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