Lyotropic liquid crystalline phases formed from glycerate surfactants as sustained release drug delivery systems

Boyd, Ben J.; Whittaker, Darryl V.; Khoo, Shui‐Mei; Davey, Greg

doi:10.1016/j.ijpharm.2005.11.033

Cited by 310 publications

(261 citation statements)

References 17 publications

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“…Glycerol monooleate being a lipid can incorporate large amount of water in it and form liquid crystalline phase. This property has been used for the developing sustained release formulation of both hydrophobic and hydrophilic drugs (Boyd et al 2006). The purpose of using oleic acid in the preparation of the nanoparticles was to stabilize the water in oil emulsions (Binks and Lumsdon 2000).…”

Section: Stability Of Ifosfamide Loaded Nanostructured Lipid Carriermentioning

confidence: 99%

Development and optimization of ifosfamide nanostructured lipid carriers for oral delivery using response surface methodology

Velmurugan

Selvamuthukumar

2015

Appl Nanosci

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The research focuses on the development and optimization of ifosfamide nanostructured lipid carriers for oral delivery with the application of response surface methodology. The objectives of the study were to develop a formulation for ifosfamide to be delivered orally, overcome the instability of the drug in acidic environment during oral administration, to sustain the release, drug leakage during storage and low loading capacity. A modified solvent diffusion method in aqueous system was applied to prepare nanostructured lipid nanoparticles. Hydrophilic polymers such as chitosan and sodium alginate were used as coating materials. Glycerol mono oleate and oleic acid were used as solid and liquid lipid, respectively. Poloxamer is used as stabilizers. The central composite rotatable design consisting of three-factored factorial design with three levels was used in this study. The physiochemical characterization included evaluation of surface morphology, particle size and surface charge of the drug in the delivery system. The in vitro drug release, entrapment and drug loading efficiency and as well as the storage stability were evaluated. The results showed that the optimal formulation was composed of drug/lipid ratio of 1:3, organic/aqueous phase ratio of 1:10 and concentration of surfactant of 1 % w/v. Ifosfamide nanostructured lipid carrier under the optimized conditions gave rise to the entrapment efficiency of 77 %, drug loading of 6.14 %, mean diameter of 223 nm and zeta potential value of -25 mV. Transmission electron microscopy analysis showed spherical particles. The in vitro experiment proved that ifosfamide from the delivery system released gradually over the period of 72 h. Sodium alginate cross-linked chitosan nanostructured lipid carrier demonstrated enhanced stability of ifosfamide, high entrapment efficiency and sustained release.

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Section: Stability Of Ifosfamide Loaded Nanostructured Lipid Carriermentioning

confidence: 99%

Development and optimization of ifosfamide nanostructured lipid carriers for oral delivery using response surface methodology

Velmurugan

Selvamuthukumar

2015

Appl Nanosci

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“…4 These mesophases are lamellar, hexagonal, or cubic 5 in shape and have attracted attention in the pharmaceutical industry as they have distinctive structures and physicochemical properties, 4 such as viscosity, bioadhesion proprieties, the ability to control the release of drugs, and loading of hydrophilic or lipophilic drugs. [6][7][8][9][10] LCs have been utilized as semisolid vehicles for topical administration of drugs. [11][12][13][14][15][16] Curcumin has a long history of use in Ayurvedic medicine treatment for inflammatory conditions 17,18 as it has an ability to inhibit nuclear factor κB.…”

Section: Introductionmentioning

confidence: 99%

Design, characterization, and biological evaluation of curcumin-loaded surfactant-based systems for topical drug delivery

Fonseca-Santos

Santos

Rodero

et al. 2016

IJN

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From previous studies, it has been found that curcumin exhibits an anti-inflammatory activity and is being used for the treatment of skin disorders; however, it is hydrophobic and has weak penetrating ability, resulting in poor drug transport through the stratum corneum. The aim of this study was to develop liquid crystalline systems for topical administration of curcumin for the treatment of inflammation. These liquid crystalline systems were developed from oleic acid, polyoxypropylene (5) polyoxyethylene (20) cetyl alcohol, and water as the surfactant, oil phase, and aqueous phase, respectively. These systems were characterized, and polarized light microscopy showed anisotropy with lamellar mesophases (Formulation 1) and hexagonal mesophases (Formulations 2 and 3), which were confirmed by the peak ratio measured using small-angle X-ray scattering. In addition, rheological tests revealed that the formulations exhibited gel-like behavior (G′>G″), as evidenced by the increased G′ values that indicate structured systems. Texture profile analysis showed that hexagonal mesophases have high values of hardness, adhesiveness, and compressibility, which indicate structured systems. In vitro studies on bioadhesion revealed that the hexagonal mesophases increased the bioadhesiveness of the systems to the skin of the pig ear. An in vivo inflammation experiment showed that the curcumin-loaded hexagonal mesophase exhibited an anti-inflammatory activity as compared to the positive control (dexamethasone). The results suggest that this system has a potential to be used as a bioadhesive vehicle for the topical administration of curcumin. Therefore, it is possible to conclude that these systems can be used for the optimization of drug delivery systems to the skin.

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“…However, there is consensus that the use of a carrier material is necessary to improve delivery of the protein, considering that it is very expensive and expands quickly from the site where it is placed. Thus, the monoolein gel in cubic phase was used as an atoxic and biodegradable matrix [36] with the ability to incorporate different lipophilic and hydrophilic substances [37], including BMPs, and to release them sustainably [11]. Although this vehicle has good properties as a delivery system for different substances, in the present study, no significant differences in the amounts of new bone tissue formed were observed between group 2 defects (pure rhBMP-2) and group 4 defects (rhBMP-2/monoolein gel), although the new bone tissue in group 2 defects was more organized than that in group 4 defects.…”

Section: Discussionmentioning

confidence: 99%

Effects of the combination of low-level laser irradiation and recombinant human bone morphogenetic protein-2 in bone repair

et al. 2011

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Low-level laser irradiation (LLLI) and recombinant human bone morphogenetic protein type 2 (rhBMP-2) have been used to stimulate bone formation. LLLI stimulates proliferation of osteoblast precursor cells and cell differentiation and rhBMP-2 recruits osteoprogenitor cells to the bone healing area. This in vivo study evaluated the effects of LLLI and rhBMP-2 on the bone healing process in rats. Critical bone defects were created in the parietal bone in 42 animals, and the animals were divided into six treatment groups: (1) laser, (2) 7 μg of rhBMP-2, (3) laser and 7 μg of rhBMP-2, (4) 7 μg of rhBMP-2/monoolein gel, (5) laser and 7 μg rhBMP-2/ monoolein gel, and (6) critical bone defect controls. A gallium-aluminum-arsenide diode laser was used (wavelength 780 nm, output power 60 mW, beam area 0.04 cm 2 , irradiation time 80 s, energy density 120 J/cm 2 , irradiance 1.5 W/cm 2 ). After 15 days, the calvarial tissues were removed for histomorphometric analysis. Group 3 defects showed higher amounts of newly formed bone (37.89%) than the defects of all the other groups (P<0.05). The amounts of new bone in defects of groups 1 and 4 were not significantly different from each other (24.00% and 24.75%, respectively), but were significantly different from the amounts in the other groups (P<0.05). The amounts of new bone in the defects of groups 2 and 5 were not significantly different from each other (31.42% and 31.96%, respectively), but were significantly different from the amounts in the other groups (P<0.05). Group 6 defects had 14.10% new bone formation, and this was significantly different from the amounts in the other groups (P<0.05). It can be concluded that LLLI administered during surgery effectively accelerated healing of critical bone defects filled with pure rhBMP-2, achieving a better result than LLLI alone or the use of rhBMP-2 alone.

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Lyotropic liquid crystalline phases formed from glycerate surfactants as sustained release drug delivery systems

Cited by 310 publications

References 17 publications

Development and optimization of ifosfamide nanostructured lipid carriers for oral delivery using response surface methodology

Development and optimization of ifosfamide nanostructured lipid carriers for oral delivery using response surface methodology

Design, characterization, and biological evaluation of curcumin-loaded surfactant-based systems for topical drug delivery

Effects of the combination of low-level laser irradiation and recombinant human bone morphogenetic protein-2 in bone repair

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