Lyophilized Sustained Release Mucoadhesive Chitosan Sponges for Buccal Buspirone Hydrochloride Delivery: Formulation and In Vitro Evaluation

Abstract

Abstract. This work aims to prepare sustained release buccal mucoadhesive lyophilized chitosan sponges of buspirone hydrochloride (BH) to improve its systemic bioavailability. Chitosan sponges were prepared using simple casting/freeze-drying technique according to 3 2 factorial design where chitosan grade was set at three levels (low, medium, and high molecular weight), and concentration of chitosan solution at three levels (0.5, 1, and 2%). Mucoadhesion force, ex vivo mucoadhesion time, percent BH released after 8 h (Q8h), and time for release of 50% BH (T 50% ) were chosen as dependent variables. Additional BH cup and core buccal chitosan sponge were prepared to achieve uni-directional BH release toward the buccal mucosa. Sponges were evaluated in terms of drug content, surface pH, scanning electron microscopy, swelling index, mucoadhesion strength, ex vivo mucoadhesion time, and in vitro drug release. Cup and core sponge (HCH 0.5E) were able to adhere to the buccal mucosa for 8 h. It showed Q8h of 68.89% and exhibited a uni-directional drug release profile following Higuchi diffusion model.

Liposomes as a Novel Ocular Delivery System for Brinzolamide: In Vitro and In Vivo Studies

“…3a, the thermogram of Brz showed a glass transition temperature at 155°C and an exothermic peak at 221°C due to Brz oxidative degradation. The glass transition peak of Brz remained in PM but disappeared in Brz-LPs, which indicated that Brz was not in a crystalline state in the lipid matrix (17)(18)(19).…”

Alginate/chitosan polyelectrolyte complexes: A comparative study of the influence of the drying step on physicochemical properties

“…The comparison of the drying process on the PECs is thus not well reported. However, in the case of alginate (Ho et al, 2004;Quraishi et al, 2015) or chitosan (Kassem, ElMeshad, & Fares, 2014;Kim & Lee, 2011) pure films, the drying influence the structure of the resulting material. Hence, we think the drying process is a key point and propose a comparative study of simple processed PECs dried with either hot air, lyophilization or SCC drying.…”

The Effect of β-Glycerophosphate Crosslinking on Chitosan Cytotoxicity and Properties of Hydrogels for Vaginal Application

“…In the recent years, mucoadhesive delivery systems providing intimate contact between a dosage form and the vaginal mucosa have gained a great attention [3,4]. Among mucoadhesive polymers, chitosan (CS) is extensively studied in designing ocular [5], buccal [6], nasal [7], and vaginal dosage forms [8,9]. In addition, CS is currently receiving great interest in pharmaceutical and biomedical fields, particularly because of its penetration enhancement capability [10,11] and antifungal activity [12][13][14].…”