Lymphovascular Invasion: Traditional but Vital and Sensible Prognostic Factor in Early Gastric Cancer

Choi, Seohee; Song, Jeong Ho; Lee, Se-Jin; Cho, Gyu Seok; Kim, Yoo Min; Kim, Wook; Hyung, Woo Jin

doi:10.1245/s10434-021-10224-6

Cited by 21 publications

(24 citation statements)

References 22 publications

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“… 12 It is known as an independent and important poor prognostic factor. 13–15 From this line of evidence, it was reasonable that intratumor CD169 + macrophages positively correlated with short cancer survival in our study. CD169, also known as Siglec1 or sialoadhesin, was originally defined as a tissue-resident macrophage-restricted surface protein that binds sized particles.…”

Section: Discussionsupporting

confidence: 63%

CD169+ Macrophages Residing in the Draining Lymph Nodes and Infiltrating the Tumor Play Opposite Roles in the Pathogenesis of Bladder Cancer

Nagata¹,

Ishizaka²,

Asano³

2023

RRU

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Purpose CD169 + macrophages are considered to enhance anti-tumor immunity by capturing lymph-borne dead tumor cells. The number of CD169 + macrophages in regional lymph nodes (RLNs) is positively correlated with prolonged cancer-free survival in various human cancers. However, a recent study argued against this dogma; that is, CD169 + macrophages infiltrating into the tumor were associated with poor prognosis in patients with breast cancer. To explain this discrepancy, we quantified the number of CD169 + macrophages located in the bladder tumor and RLNs of the same patients and examined their relationship with the 5-year survival rate. Patients and Methods Tumor and RLN specimens resected from 40 invasive bladder cancer patients (29 males and 11 females; median age, 70.7 years; range, 49–81 years) who underwent radical cystectomy were evaluated using immunostaining. Results The number of CD169 + macrophages in RLNs was associated with a good cancer prognosis, while CD169 + macrophages infiltrating the tumor strongly correlated with a higher incidence of lymphovascular invasion. Conclusion CD169 + macrophages play opposing roles in the induction of anti-tumor immunity based on their location in RLNs or tumors.

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Section: Discussionsupporting

confidence: 63%

CD169+ Macrophages Residing in the Draining Lymph Nodes and Infiltrating the Tumor Play Opposite Roles in the Pathogenesis of Bladder Cancer

Nagata¹,

Ishizaka²,

Asano³

2023

RRU

View full text Add to dashboard Cite

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“…Although the American Joint Committee on Cancer (AJCC) was considered the gold standard to predict outcome generally, it failed to predict heterogeneous survival rates individually in GC patients with the same stage ( 3 , 4 ). Recently, studies have revealed that lymphovascular invasion (LVI) was associated with recurrence and prognosis in GC patients ( 5 , 6 ), patients in LVI positive status after surgery presented with higher possibility of recurrence and poorer 5 years’ survival. Thus, some researchers ( 7 , 8 ) recommended combining LVI in risk stratification of prognosis and selection criteria for the need of adjuvant therapies to improve overall survival in GC patients.…”

Section: Introductionmentioning

confidence: 99%

Spectral CT for preoperative prediction of lymphovascular invasion in resectable gastric cancer: With external prospective validation

Wang

et al. 2022

Front. Oncol.

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ObjectivesTo develop and externally validate a spectral CT based nomogram for the preoperative prediction of LVI in patients with resectable GC.MethodsThe two centered study contained a retrospective primary dataset of 224 pathologically confirmed gastric adenocarcinomas (161 males, 63 females; mean age: 60.57 ± 10.81 years, range: 20-86 years) and an external prospective validation dataset from the second hospital (77 males and 35 females; mean age, 61.05 ± 10.51 years, range, 31 to 86 years). Triple-phase enhanced CT scans with gemstone spectral imaging mode were performed within one week before surgery. The clinicopathological characteristics were collected, the iodine concentration (IC) of the primary tumours at arterial phase (AP), venous phase (VP), and delayed phase (DP) were measured and then normalized to aorta (nICs). Univariable analysis was used to compare the differences of clinicopathological and IC values between LVI positive and negative groups. Independent predictors for LVI were screened by multivariable logistic regression analysis in primary dataset and used to develop a nomogram, and its performance was evaluated by using ROC analysis and tested in validation dataset. Its clinical use was evaluated by decision curve analysis (DCA).ResultsTumor thickness, Borrmann classification, CT reported lymph node (LN) status and nICDP were independent predictors for LVI, and the nomogram based on these indicators was significantly associated with LVI (P<0.001). It yielded an AUC of 0.825 (95% confidence interval [95% CI], 0.769-0.872) and 0.802 (95% CI, 0.716-0.871) in primary and validation datasets (all P<0.05), with promising clinical utility by DCA.ConclusionThis study presented a dual energy CT quantification based nomogram, which enables preferable preoperative individualized prediction of LVI in patients with GC.

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“…In previous studies, it only existed in surgical pathology reports, and its molecular biology is poorly understood. It is used to evaluate the survival prognosis of early gastric cancer in the past, patients with positive LVI should be considered as candidates for adjuvant chemotherapy [ 18 , 19 ]. Similarly, the study has found that LVI is an independent predictor of survival in breast cancer after neoadjuvant chemotherapy, some scholars also have found that the occurrence of LVI is significantly related to luminal B with HER2(-), and the basal-like subtype [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Predicting Axillary Response in Hormone Receptor-Positive Breast Cancer after Neoadjuvant Chemotherapy Using Real-World Data

Qiu

Zheng

et al. 2022

Journal of Oncology

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Purpose. To develop a scoring system for hormone receptor-positive (HR+) breast cancer patients who are expected to achieve axillary pathological complete response (pCR) after neoadjuvant chemotherapy (NAC). To confirm the correlation between axillary status and survival rate in HR+ breast cancer after NAC. Methods. Women from the Shanghai Jiao Tong University Breast Cancer Database (SJTU-BCDB) who underwent NAC for cT1-4N1-3M0 primary HR+ breast cancer between 2009 and 2018 were included in the study. In this case, patient follow up was performed until 2022 for those with complete data before and after NAC. The main outcome measures were the axillary pCR rate, overall survival (OS), and disease-free survival (DFS). The patients were randomly assigned to a test set (n = 175) and a validation set (n = 68) in a 7 : 3 ratio. A prediction risk score was then developed based on the odds ratios from the multivariate analysis of the test set (n = 175) before being validated in the validation set (n = 68). Finally, the Kaplan–Meier curves were used to explore the survival on this score system. Results. From the database, 243 women were included, and the median follow-up period was 47.5 months (95% confidence interval: 41.9–53.1). The axillary pCR rate was 18.9% (46 of 243), with the independent predictors of residual positive axillary lymph nodes (LNs) being lymphovascular invasion (LVI), breast conserving surgery (BCS), Ki67 < 14%, HER2 negativity, positive lymph nodes in ultrasound (US) before surgery, and stage III histological grade (All, P < 0.05 ). Using the above predictors of the model, the receiver operating characteristic (ROC) curve was used for calibration and inspection, with values for the test and validation sets being 0.847 ( P < 0.001 ; 95% CI: 0.769, 0.925) and 0.813 ( P < 0.001 ; 95% CI: 0.741, 0.885), respectively. The total risk score ranged from 0 to 6 for the multivariate analysis, and from this range, a risk score of 0–2 was defined as a low-risk group, while scores of 3–6 were defined as the high-risk one. By constructing the survival curve, it was found that the 5-year OS rates for the low-risk and high-risk groups were 89.0% and 84.2% (P = 0.236). Similarly, the 5-year DFS rates for the low-risk and high-risk groups were 80% and 68.5% (P = 0.048), respectively. In addition, axillary pathological stages were significantly correlated with the overall survival (OS) and disease-free survival (DFS) (All, P < 0.05 ). Conclusion. The prediction model showed good performance for HR + breast cancer. LVI, BCS, low Ki-67, HER2 negativity, suspected positive LNs before surgery, and stage III histological grade were all risk factors for residual positive axillary LNs. However, unlike pathological stages, achieving pCR in the axillary LNs does not affect the survival status.

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Lymphovascular Invasion: Traditional but Vital and Sensible Prognostic Factor in Early Gastric Cancer

Cited by 21 publications

References 22 publications

CD169+ Macrophages Residing in the Draining Lymph Nodes and Infiltrating the Tumor Play Opposite Roles in the Pathogenesis of Bladder Cancer

CD169+ Macrophages Residing in the Draining Lymph Nodes and Infiltrating the Tumor Play Opposite Roles in the Pathogenesis of Bladder Cancer

Spectral CT for preoperative prediction of lymphovascular invasion in resectable gastric cancer: With external prospective validation

Predicting Axillary Response in Hormone Receptor-Positive Breast Cancer after Neoadjuvant Chemotherapy Using Real-World Data

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