Lymphovascular Invasion of Urothelial Cancer in Matched Transurethral Bladder Tumor Resection and Radical Cystectomy Specimens

Kunju, Lakshmi P.; Li, You; Zhang, Yingxi; Daignault, Stephanie; Montie, James E.; Lee, Cheryl T.

doi:10.1016/j.juro.2008.07.056

Cited by 60 publications

(35 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These results are similar to previous studies of pT1 urothelial cancers removed by RC, in which LVI was found in 5-10% of patients, and was an important prognostic factor for recurrence free survival and CSS. 19,22,23 Additional studies are required to ascertain whether LVI can be reliably and accurately detected in biopsies, and used to identify patients who might benefit from early cystectomy.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Reporting trends and prognostic significance of lymphovascular invasion in muscle‐invasive urothelial carcinoma: A population‐based study

et al. 2014

View full text Add to dashboard Cite

Abbreviations & AcronymsObjectives: To investigate reporting patterns and outcomes associated with lymphovascular invasion in a general population setting. Methods: We identified all cystectomy patients with muscle-invasive urothelial cancer in Ontario, Canada, 1994-2008. Surgical pathology reports were analyzed for pathological variables including lymphovascular invasion. Lymphovascular invasion reporting patterns were described over time. A Cox proportional hazards model was used to evaluate the association of lymphovascular invasion with survival. Results: Of the 2802 cases identified, lymphovascular invasion status was reported in 75%. Lymphovascular invasion reporting significantly improved over the study period and was correlated with poor prognostic pathological features (T stage and N stage). Comprehensive cancer center status was not consistently associated with lymphovascular invasion reporting. Patients with lymphovascular invasion had substantially lower survival than patients who were lymphovascular invasion-negative or whose lymphovascular invasion status was unstated (P < 0.001). Lymphovascular invasion was independently associated with survival in patients regardless of lymph node metastasis. After adjusting for age, stage, comorbidity, margin status and adjuvant chemotherapy, lymphovascular invasion remained strongly associated with reduced survival (hazard ratio 1.98, 95% confidence interval 1.71-2.29). Conclusions: Although routine reporting of lymphovascular invasion has improved over the years, pathologists appear to be biased towards evaluating lymphovascular invasion in patients with high-stage disease. Despite this bias, lymphovascular invasion remains an important prognostic factor among patients treated by cystectomy. Pathologists in general practice should report lymphovascular invasion status more consistently and urologists should hold their pathology colleagues to a higher standard.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Methods: We identified all cystectomy patients with muscle-invasive urothelial cancer in Ontario, Canada, 1994-2008. Surgical pathology reports were analyzed for pathological variables including lymphovascular invasion.…”

mentioning

confidence: 99%

Reporting trends and prognostic significance of lymphovascular invasion in muscle‐invasive urothelial carcinoma: A population‐based study

et al. 2014

View full text Add to dashboard Cite

show abstract

“…The prognostic value of lymphovascular invasion (LVI) has previously been investigated by others [8,9].…”

Section: Introductionmentioning

confidence: 99%

The Importance of Lymphovascular Invasion at Radical Cystectomy

Görgel¹

2015

CMR

View full text Add to dashboard Cite

Abstract:Objectives: To investigate relationship between the lymphovascular invasion(LVI) and tumor characteristics and to evaluate effect on survival of LVI in patients who underwent radical cystectomy because of bladder cancer. Materials and Methods: Five hundred and six patients were enrolled the study between 1990 and 2013. Patients were divided into two groups in terms of lymphovascular invasion at final pathology after radical cystectomy. There were 108 patients with LVI(group1) and 244 patients without LVI(group2).

show abstract

“…Last year, an interesting study was published revealing significant agreement of lvi status at transurethral bladder tumour resection (tur-tm) and at subsequent cystectomy 3 . In our opinion, histologic evaluation of tur-tm and of cystectomy specimens in terms of the appearance of lvi should provide valuable prognostic data during follow-up.…”

mentioning

confidence: 99%

“…When lymphovascular invasion is identified in a transurethral bladder tumour resection sample, it will be present in the cystectomy sample in 65% of cases and associated with nodal metastasis in 41% 3 . It is not surprising that lvi is identified more frequently in cystectomy specimens, because a far greater amount of tumour is available for examination.…”

mentioning

confidence: 99%

Lymphovascular Invasion as a Predictive Factor for Muscle-Invasive Bladder Cancer and Its Importance in a Bladder-Conservation Treatment Group

Tokgöz

Erol

2010

Current Oncology

View full text Add to dashboard Cite

Lymphovascular Invasion of Urothelial Cancer in Matched Transurethral Bladder Tumor Resection and Radical Cystectomy Specimens

Cited by 60 publications

References 11 publications

Reporting trends and prognostic significance of lymphovascular invasion in muscle‐invasive urothelial carcinoma: A population‐based study

Reporting trends and prognostic significance of lymphovascular invasion in muscle‐invasive urothelial carcinoma: A population‐based study

The Importance of Lymphovascular Invasion at Radical Cystectomy

Lymphovascular Invasion as a Predictive Factor for Muscle-Invasive Bladder Cancer and Its Importance in a Bladder-Conservation Treatment Group

Contact Info

Product

Resources

About