“…Malek et al 58 reported that high molecular weight sulfonic acid salts of several parenterally administered antibiotics produced sustained, but lower plasma levels, whilst retaining higher lymph concentrations. Massey 59 utilized a sulfonate salt of cephalexin to enhance both the absorption and stability of the API.…”
“…Malek et al 58 reported that high molecular weight sulfonic acid salts of several parenterally administered antibiotics produced sustained, but lower plasma levels, whilst retaining higher lymph concentrations. Massey 59 utilized a sulfonate salt of cephalexin to enhance both the absorption and stability of the API.…”
“…89 Transport of monoclonal antibodies and radiolabeled macromolecules including dextran, albumin, and hydroxyethyl starch via the lymphatics has also been extensively examined in relation to imaging agents in lymphoscintigraphic studies, although the absolute extent of lymphatic transport has rarely been quantified. [90][91][92][93][94][95] Muranishi and co-workers 96 also utilized the lymph-directing qualities of dextran macromolecules by forming a dextran (MW 500,000) prodrug of bleomycin (BLM) to enhance delivery to the regional lymph nodes after injection into the stomach wall of the rat.…”
Section: Factors Affecting Lymphatic Transport Of Proteins After Scmentioning
“…MQlek et al (18) devised a unique way of prolonging action through salt formation; they showed that the distribution of several antibiotics could be markedly altered by merely preparing macromolecular salts. Since macromolecules and colloidal particles have an affinity for the lymphatic system, streptomycin, neomycin, viomycin, and streptothrycin were combined with high molecular weight compounds such as polyacrylic acids, sulfonic or phosphorylated polysaccharides, and polyuronic derivatives.…”
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